Pyruvate Kinase

Known as: phosphoenol transphosphorylase, Pyruvate Kinase [Chemical/Ingredient], kinase pyruvate 
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
010020019512017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of… (More)
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Highly Cited
2012
Highly Cited
2012
Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by… (More)
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Highly Cited
2011
Highly Cited
2011
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters… (More)
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Highly Cited
2011
Highly Cited
2011
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in… (More)
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Highly Cited
2011
Highly Cited
2011
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even in the presence of normal… (More)
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Highly Cited
2010
Highly Cited
2010
When oxygen is abundant, quiescent cells efficiently extract energy from glucose primarily by oxidative phosphorylation, whereas… (More)
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Highly Cited
2010
Highly Cited
2010
Cancer cells preferentially metabolize glucose by aerobic glycolysis, characterized by increased lactate production. This… (More)
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Highly Cited
2008
Highly Cited
2008
Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high… (More)
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Highly Cited
2008
Highly Cited
2008
Growth factors stimulate cells to take up excess nutrients and to use them for anabolic processes. The biochemical mechanism by… (More)
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Highly Cited
2002
Highly Cited
2002
The intracellular carbon flux distribution in wild-type and pyruvate kinase-deficient Escherichia coli was estimated using… (More)
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