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Prothionamide

Known as: PROTIONAMIDE, 2-Propylpyridine-4-carbothioamide, Prothionamide [Chemical/Ingredient] 
A thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (1)

Antitubercular Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (3)

Petehaektebinisoprodian

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Anti-tubercular activity of some six membered heterocycle compounds
The effectiveness in TB treatment is difficult because the structural composition of the mycobacterial cell wall is very… 
Review
2014
Review
2014
Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex.
OBJECTIVES Sequence analysis of known antibiotic resistance genes of the Mycobacterium tuberculosis complex (MTBC) is… 
2010
2010
Highly Effective , and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
Rationale: Based on expert opinion, the global guidelines for management of multidrug-resistant tuberculosis impose lengthy and… 
2009
2009
Pharmacokinetics of prothionamide in patients with multidrug-resistant tuberculosis.
SETTING National Masan Tuberculosis Hospital, Masan, South Korea. OBJECTIVE To evaluate the pharmacokinetics of prothionamide… 
Review
2004
Review
2004
A Decade Surveillance Study of Mycobacterium xenopi Disease and Antimicrobial Susceptibility Levels in a Reference Teaching Hospital of Northern Italy: HIV-Associated Versus Non-HIV-Associated…
Abstract Objective and Method: The aim of our survey is to investigate the epidemiology and in vitro antimicrobial susceptibility… 
1998
1998
Simple, rapid and sensitive determination of protionamide in human serum by high-performance liquid chromatography.
1996
1996
[Resistant lung tuberculosis in Berlin 1987-1993].
Resistance of Mycobacterium tuberculosis (M. tb) strains is an increasing problem worldwide. Since no public health data are… 
1987
1987
Plasma levels of ethionamide and prothionamide in a volunteer following intravenous and oral dosages.
Les parametres pharmacocinetiques des medicaments sont tres comparables, chacun presentant une biodisponibilite elevee et d… 
1985
1985
Hepatotoxicity of the daily combination of 5 mg/kg prothionamide + 10 mg/kg rifampin.
Because a 13% incidence of hepatotoxicity was observed in a first study of multibacillary leprosy patients treated daily with… 
1984
1984
A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man.
The blood levels and urinary excretion of the anti-mycobacterial drugs ethionamide and prothionamide have been compared after… 
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