Protein Aggregates

Known as: Aggregates, Protein, Protein Aggregates [Chemical/Ingredient] 
Any mixture of secondary, tertiary, or quaternary protein molecules which appear as clumps in or outside the cell.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2018
010020019652018

Papers overview

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Review
2017
Review
2017
Progression of pathology in neurodegenerative diseases is hypothesized to be a non-cell-autonomous process that may be mediated… (More)
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Highly Cited
2010
Highly Cited
2010
To evaluate the nanoparticle tracking analysis (NTA) technique, compare it with dynamic light scattering (DLS) and test its… (More)
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Highly Cited
2007
Highly Cited
2007
Protein degradation by basal constitutive autophagy is important to avoid accumulation of polyubiquitinated protein aggregates… (More)
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Highly Cited
2007
Highly Cited
2007
The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal… (More)
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Highly Cited
2005
Highly Cited
2005
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic… (More)
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Highly Cited
2004
Highly Cited
2004
The intracellular free Ca(2+) concentration and redox status of murine fibroblasts exposed to prefibrillar aggregates of the HypF… (More)
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Highly Cited
2003
Highly Cited
2003
The efficient clearance of cytotoxic misfolded protein aggregates is critical for cell survival. Misfolded protein aggregates are… (More)
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Highly Cited
2002
Highly Cited
2002
Protein aggregation and the formation of inclusion bodies are hallmarks of the cytopathology of neurodegenerative diseases… (More)
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Highly Cited
1999
Highly Cited
1999
A major activity of molecular chaperones is to prevent aggregation and refold misfolded proteins. However, when allowed to form… (More)
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Highly Cited
1998
Highly Cited
1998
Intracellular deposition of misfolded protein aggregates into ubiquitin-rich cytoplasmic inclusions is linked to the pathogenesis… (More)
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