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Protac snake venom protein C activator

Known as: Protac 
 
National Institutes of Health

Papers overview

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2020
2020
Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4
Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug… Expand
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2019
2019
MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53.
Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number… Expand
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2019
2019
PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding.
The impact of covalent binding on PROTAC-mediated degradation of BTK was investigated through the preparation of both covalent… Expand
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2019
2019
PROTAC-mediated crosstalk between E3 ligases.
Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled… Expand
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2019
2019
Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation.
While the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients… Expand
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2019
2019
Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
Proteolysis targeting chimeras (PROTACs) are an emerging strategy for promoting targeted protein degradation by inducing the… Expand
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Highly Cited
2017
Highly Cited
2017
Structural basis of PROTAC cooperative recognition for selective protein degradation
Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs… Expand
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2014
2014
Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus.
The X-protein of the hepatitis B virus (HBV) is essential for virus infection and contributes to the development of HBV-induced… Expand
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2004
2004
Targeted degradation of proteins by small molecules: a novel tool for functional proteomics.
A novel strategy that targets protein for degradation has recently been developed by exploiting a protein-targeting chimeric… Expand
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Highly Cited
2003
Highly Cited
2003
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation*
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human… Expand
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