Protac snake venom protein C activator

Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs… (More)

Selective degradation of proteins by proteolysis targeting chimeras (PROTACs) offers a promising potential alternative to protein… (More)

PURPOSE Smad3 is a critical signaling protein in renal fibrosis. Proteolysis targeting chimeric molecules (PROTACs) are small… (More)

The X-protein of the hepatitis B virus (HBV) is essential for virus infection and contributes to the development of HBV-induced… (More)

Protein degradation is one of the tactics used by the cell for irreversibly inactivating proteins. In eukaryotes, ATP-dependent… (More)

A novel strategy that targets protein for degradation has recently been developed by exploiting a protein-targeting chimeric… (More)

The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human… (More)