Prophylactic Cranial Irradiation

Known as: PCI 
Radiation therapy to the head to reduce the risk that cancer will spread to the brain.
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Prophylactic cranial irradiation for patients with lung cancer.
The incidence of brain metastases in patients with lung cancer has increased as a result of improved local and systemic control… (More)
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Review
2011
Review
2011
Prophylactic cranial irradiation in lung cancer.
As multi-modality treatments are now able to ensure better local control and a lower rate of extra cranial metastases, brain… (More)
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Highly Cited
2011
Highly Cited
2011
Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis.
PURPOSE There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and… (More)
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Highly Cited
2011
Highly Cited
2011
Phase III comparison of prophylactic cranial irradiation versus observation in patients with locally advanced non-small-cell lung cancer: primary analysis of radiation therapy oncology group study…
PURPOSE This study was conducted to determine if prophylactic cranial irradiation (PCI) improves survival in locally advanced non… (More)
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Highly Cited
2009
Highly Cited
2009
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
BACKGROUND Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who… (More)
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Highly Cited
2009
Highly Cited
2009
Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI…
BACKGROUND The optimum dose of prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC) is unknown… (More)
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2007
2007
Prophylactic cranial irradiation in extensive small-cell lung cancer.
BACKGROUND We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer… (More)
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Highly Cited
2003
Highly Cited
2003
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
The generation of new neurons in the adult mammalian brain has been documented in numerous recent reports. Studies undertaken so… (More)
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Highly Cited
1995
Highly Cited
1995
Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission.
BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain… (More)
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1973
1973
Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukaemia.
A transient cerebral disturbance characterized by somnolence of varying degree is described in children after cranial irradiation… (More)
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