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Pretargeted Radioimmunotherapy
A technique used to improve the efficacy of radioimmunotherapy that targets the tumor with both an antibody construct and a radiolabeled hapten prior…
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National Institutes of Health
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Papers overview
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2015
2015
Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity [superscript 86]Y- or [superscipt 177]Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific…
S. Cheal
,
Hong Xu
,
+12 authors
S. Larson
2015
Corpus ID: 99074989
Purpose GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We…
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2014
2014
Therapeutics , Targets , and Chemical Biology A Preclinical Model of CD 38-Pretargeted Radioimmunotherapy for Plasma Cell Malignancies
D. Green
,
N. Orgun
,
+14 authors
O. Press
2014
Corpus ID: 38203328
The vast majority of patients with plasma cell neoplasms die of progressive disease despite high response rates to novel agents…
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2012
2012
Pretargeted radioimmunodetection and -therapy in colorectal cancer
R. Schoffelen
2012
Corpus ID: 68842296
2011
2011
In vivo chemistry for pretargeted RIT of cancer
R. Rossin
,
S. M. van den Bosch
,
T. Läppchen
,
Roland C. M. Vulders
,
J. Lub
,
M. Robillard
2011
Corpus ID: 172903580
2011
2011
Cancer Therapy : Preclinical Pretargeted Radioimmunotherapy Using Genetically Engineered Antibody-Streptavidin Fusion Proteins for Treatment of Non-Hodgkin Lymphoma
Steven I. Park
,
J. Shenoi
,
+13 authors
O. Press
2011
Corpus ID: 40502598
Purpose: Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of…
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2010
2010
Abstract 4552: Pretargeted radioimmunoimaging and -therapy in tumor-bearing mice using a bioorthogonal reaction
R. Rossin
,
P. R. Verkerk
,
+4 authors
M. Robillard
2010
Corpus ID: 75715732
A major challenge of radioimmunotherapy (RIT) of cancer is to enhance the nuclear radiation dose delivered to the tumor while…
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2009
2009
Protein engineering for targeted delivery of radionuclides to tumors
K. Orcutt
2009
Corpus ID: 106978480
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2010.
2009
2009
Anti-CD45 Ab Pretargeted Radioimmunotherapy Using An Alpha Emitting Radionuclide (213Bi) Delivers Selective Radiation to Human Myeloid Leukemias in a Mouse Xenograft Model and Results in High Rates…
Aimee L. Kenoyer
,
O. Press
,
+13 authors
J. Pagel
2009
Corpus ID: 208436468
Abstract 1035 Poster Board I-57 Little change has been seen over the past two decades in the progression-free survival of…
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2006
2006
Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer
Stefan C. Zajic
2006
Corpus ID: 93549076
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2007.
1999
1999
Pretargeted Radioimmunotherapy (PRITR) for Treatment of Non-Hodgkin's Lymphoma (NHL): Preliminary Results
H. Breitz
,
P. Weiden
,
+5 authors
P. Abrams
1999
Corpus ID: 68693196