FAQ

Pre-mRNA 3'-End-Processing Factor FIP1

Known as: Rhe, Factor Interacting with PAP, hFip1 
Pre-mRNA 3'-end-processing factor FIP1 (594 aa, ~67 kDa) is encoded by the human FIP1L1 gene. This protein is involved in the polyadenylation of mRNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
051019992017

Related topics

Related topics

6 relations
Cell NucleusFIP1L1 geneFIP1L1 wt AlleleGenes, Regulator
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Pre-mRNA 3'-End-Processing Factor FIP1
Cell Nucleus
Genes, Regulator
RNA Processing
RNA-Binding Proteins
FIP1L1 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription… (More)
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Highly Cited
2007
Highly Cited
2007
The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study.
BACKGROUND AND OBJECTIVES The hypereosinophilic syndrome (HES) may be associated with the fusion of the platelet derived growth… (More)
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2007
2007
Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation.
An interstitial deletion on chromosome 4q12 resulting in the formation of the FIP1L1-PDGFRA fusion protein is involved in the… (More)
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2006
2006
Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.
Genetic abnormalities that result in expression of chimeric tyrosine kinase proteins such as BCR-ABL1 and ETV6-PDGFRbeta are… (More)
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Highly Cited
2005
Highly Cited
2005
Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.
At least half of all human pre-mRNAs are subject to alternative 3' processing that may modulate both the coding capacity of the… (More)
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2005
2005
Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics
Idiopathic hypereosinophilic syndrome (HES) characterized by unexplained and persistent hypereosinophilia is heterogeneous and… (More)
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Highly Cited
2004
Highly Cited
2004
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.
In mammals, polyadenylation of mRNA precursors (pre-mRNAs) by poly(A) polymerase (PAP) depends on cleavage and polyadenylation… (More)
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2004
2004
The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
We recently identified the chimeric kinase FIP1L1-platelet-derived growth factor receptor alpha (PDGFRalpha) as a cause of the… (More)
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Highly Cited
2003
Highly Cited
2003
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
BACKGROUND Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It… (More)
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Highly Cited
2003
Highly Cited
2003
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy.
Imatinib mesylate is effective in the treatment of hematologic malignancies that are characterized by either abl- or PDGFR beta… (More)
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