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Pre-mRNA 3'-End-Processing Factor FIP1

Known as: Rhe, Factor Interacting with PAP, hFip1 
Pre-mRNA 3'-end-processing factor FIP1 (594 aa, ~67 kDa) is encoded by the human FIP1L1 gene. This protein is involved in the polyadenylation of mRNA… 
National Institutes of Health

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6 relations
Cell NucleusFIP1L1 geneFIP1L1 wt AlleleGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Generation of the Fip1l1–Pdgfra fusion gene using CRISPR/Cas genome editing
The FIP1L1-PDGFRA fusion gene is an important oncogenic driver of chronic eosinophilic leukemia, now referred to as the WHO… 
2016
2016
Chromatin Conformation Signatures Associated with Epigenetic Deregulation of the FIP1L1 and PDGFRA Genes
The human genome is organized into topological domains with discrete structural and regulatory units that influence gene… 
2012
2012
Complete Response of Myeloid Sarcoma with FIP1L1-PDGFRA-Associated Myeloproliferative Neoplasms to Imatinib Mesylate Monotherapy
Myeloid sarcoma (MS) is a localized, extramedullary tumor of acute myeloid leukemia (AML) that typically presents either de novo… 
2008
2008
Eosinophilia with FIP1L1-PDGFRA fusion in a patient with chronic myelomonocytic leukemia.
A 67-year-old woman with a past medical history of alfathalassemia trait was referred to our medical center for evaluation of… 
2008
2008
Early discharge from hospital after consolidation chemotherapy in acute myeloid leukemia in remission: febrile neutropenic episodes and their outcome in a resource poor setting
Treatment of acute myeloid leukemia (AML) involves administration of myelosuppressive chemotherapy administered after admittance… 
2006
2006
Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia.
Idiopathic hypereosinophilic syndrome (HES) and chronic eosinophilic leukemia (CEL) are related hematological malignancies… 
2006
2006
Chronic Eosinophilic Leukemia with the FIP1L1-PDGFR± Fusion Gene in a Patient with a History of Combination Chemotherapy
Hypereosinophilic syndrome (HES) was diagnosed in December 2000 in a 43-year-old man on the basis of persistent eosinophilia (11… 
Highly Cited
2004
Highly Cited
2004
The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
We recently identified the chimeric kinase FIP1L1-platelet-derived growth factor receptor alpha (PDGFRalpha) as a cause of the… 
2004
2004
Chromosome Banding Analysis, FISH and RT-PCR Performed in Parallel in Hypereosinophilic Syndrome Establishes the Diagnosis of Chronic Eosinophilic Leukemia in 22% of Cases: A Study on 40 Patients.
Hypereosinophilia is a common biological finding. When thorough evaluation of a patient with chronic hypereosinophilia fails to… 
2004
2004
[Identification of FIP1L1-PDGFRA fusion, and expression of signal transducer and activator of transcription 5 in hypereosinophilic syndrome].
OBJECTIVE To determine whether FIP1L1-PDGFRA fusion exists in hypereosinophilic syndrome (HES) patients, explore the relationship… 
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