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Prajmaline

Known as: Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21alpha)-, N-Propylajmaline, Prajmaline [Chemical/Ingredient] 
A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Anti-Arrhythmia Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

Neo-GilurytmalPrajmalium Bitartrate

Papers overview

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2005
2005
Differential effects of Na-K-ATPase pump inhibition, chemical anoxia, and glycolytic blockade on membrane potential of rat optic nerve
1990
1990
Comparative Analysis of the Action of Class I Antiarrhythmic Drugs (Lidocaine, Quinidine, and Prajmaline) in Rabbit Atrial and Ventricular Myocardium
Effects of three class I antiarrhythmic drugs (quinidine, lidocaine, and prajmaline) on transmembrane resting (RMP) and action… 
1985
1985
Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation
SummaryIn order to determine whether the metabolism of the antiarrhythmic drug N-propylajmaline is under the same genetic control… 
1985
1985
Properties ofVmax block of INa-mediated action potentials during combined application of antiarrhythmic drugs in cardiac muscle
SummaryModifications of drug-inducedVmax inhibition by the combined treatment of the cardiac membrane with several class 1… 
1983
1983
Comparison of tocainide and prajmalium bitartrate for the treatment of ventricular arrhythmias.
The antiarrhythmic efficacy of tocainide, a new antiarrhythmic substance, has been compared with that of prajmalium bitartrate, a… 
1981
1981
Evaluation of prajmalium-induced cholestasis by immunologic tests.
Cholestatic jaundice developed in four patients after the administration of prajmalium bitartrate. The clinical, histologic… 
1981
1981
Experience with immunological tests in drug-induced hepatitis.
Nine patients are reported who developed hepatic injury following the administration of therapeutic agents. The drugs… 
1978
1978
Orally administered prajmalium bitartrate in acute and chronic ventricular arrhythmias.
1977
1977
A kinetic study of effects of propranolol and N-propylajmaline on the rate of rise of action potential in guinea pig papillary muscles.
Abstract. In isolated guinea pig papillary muscles driven at 1 Hz, propranolol in the concentrations of 10-6, 2 × 10-6 and 5 × 10… 
1976
1976
[Prajmalium bitartrat-induced liver damage (author's transl)].
Liver damage was found in five patients (three men, two women) who were receiving prajmalium bitartrate. The cause was proven by… 
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