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Polyamine Synthesis Inhibitor

Known as: Polyamine Inhibitor 
A compound that inhibits the synthesis of the naturally occurring polyamines, intracellular compounds that bind to DNA and play a critical role in… 
National Institutes of Health

Papers overview

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2000
2000
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment…
A single-agent dose-escalating Phase I and pharmacological study of the polyamine synthesis inhibitor SAM 486A was performed. A… 
1998
1998
Apoptosis induction in human breast cancer MRK-nu-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)(MGBCP).
We have investigated the antiproliferative effects of a polyamine synthesis inhibitor, methylglyoxal bis… 
1997
1997
The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis
The treatment of late‐stage human African trypanosomiasis is complicated by a post‐treatment reactive encephalopathy, also… 
1997
1997
Induction of apoptotic cell death in three human osteosarcoma cell lines by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP).
Our previous experiments have shown that methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP), a polyamine synthesis inhibitor… 
1994
1994
Abnormal DNA synthesis in polyamine deficient cells revealed by bromodeoxyuridine—flow cytometry technique
Abstract. Chinese hamster ovary cells were seeded in the absence or presence of the polyamine synthesis inhibitor 2… 
1988
1988
Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia
Cationic compounds used in the treatment of veterinary African trypanosomiasis have structural properties similar to those of… 
1988
1988
Pharmacological Investigations on the Lipolytic and Antilipolytic Effects of Growth Hormone (GH) in Chicken Adipose Tissue in Vitro: Evidence for Involvement of Calcium and Polyamines
Abstract The involvement of RNA/protein synthesis, calcium, calmodulin, protein kinase C, and polyamines in the lipolytic and… 
1987
1987
Combination therapy using polyamine synthesis inhibitor alpha‐difluoromethylornithine and adriamycin in treatment of rats carrying the dunning R3327 MAT‐LyLu prostatic adenocarcinoma
Prostate cells of human and rat origin produce polyamines in high content, whose apparent functions relate to cellular… 
1984
1984
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
The uptake of exogenously administered radiolabeled polyamines by a rat prostate-derived tumor line, the Dunning R3327 MAT-Lu… 
1983
1983
Differential potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine in chloroethylnitrosourea-sensitive and -resistant 9L rat brain tumor cells in vitro.
alpha-Difluoromethylornithine, an enzyme-activated, irreversible inhibitor of ornithine decarboxylase, inhibited the growth of… 
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