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Polyamine Synthesis Inhibitor

Known as: Polyamine Inhibitor 
A compound that inhibits the synthesis of the naturally occurring polyamines, intracellular compounds that bind to DNA and play a critical role in… 
National Institutes of Health

Papers overview

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1998
1998
Apoptosis induction in human breast cancer MRK-nu-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)(MGBCP).
We have investigated the antiproliferative effects of a polyamine synthesis inhibitor, methylglyoxal bis… 
1997
1997
Induction of apoptotic cell death in three human osteosarcoma cell lines by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP).
Our previous experiments have shown that methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP), a polyamine synthesis inhibitor… 
1997
1997
Growth inhibition of Helicobacter pylori by apolyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)
The anti‐proliferative effect of methylglyoxal bis(cyclopentyl‐amidino‐hydrazone) (MGBCP), a multi‐enzyme inhibitor of polyamine… 
1994
1994
Abnormal DNA synthesis in polyamine deficient cells revealed by bromodeoxyuridine—flow cytometry technique
Abstract. Chinese hamster ovary cells were seeded in the absence or presence of the polyamine synthesis inhibitor 2… 
1992
1992
Role of polyamines in regulation of uterine blood flow of ovariectomized rats.
1988
1988
Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia
Cationic compounds used in the treatment of veterinary African trypanosomiasis have structural properties similar to those of… 
1987
1987
Combination therapy using polyamine synthesis inhibitor alpha‐difluoromethylornithine and adriamycin in treatment of rats carrying the dunning R3327 MAT‐LyLu prostatic adenocarcinoma
Prostate cells of human and rat origin produce polyamines in high content, whose apparent functions relate to cellular… 
1986
1986
alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor.
1984
1984
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
The uptake of exogenously administered radiolabeled polyamines by a rat prostate-derived tumor line, the Dunning R3327 MAT-Lu… 
1983
1983
Differential potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine in chloroethylnitrosourea-sensitive and -resistant 9L rat brain tumor cells in vitro.
alpha-Difluoromethylornithine, an enzyme-activated, irreversible inhibitor of ornithine decarboxylase, inhibited the growth of… 
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