FAQ

Platinum Antineoplastic Compound

Known as: Platinum Agents, Platinum Compound, Platinum compounds 
A chemotherapy compound that contains a platinum atom. Platinum compounds do not contain alkyl groups but do cause DNA crosslinks and adducts similar… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2017
0204019662017

Papers overview

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Highly Cited
2011
Highly Cited
2011
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
BACKGROUND Breast cancer cells deficient for BRCA1 are hypersensitive to agents inducing DNA double-strand breaks (DSB), such as… (More)
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Highly Cited
2011
Highly Cited
2011
Recent progress in the diagnosis and treatment of ovarian cancer.
Epithelial ovarian cancer is the most lethal of the gynecologic malignancies, largely due to the advanced stage at diagnosis in… (More)
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Highly Cited
2009
Highly Cited
2009
Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.
The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies… (More)
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Highly Cited
2008
Highly Cited
2008
Capecitabine and oxaliplatin for advanced esophagogastric cancer.
BACKGROUND We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused… (More)
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Highly Cited
2006
Highly Cited
2006
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN… (More)
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Highly Cited
2005
Highly Cited
2005
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells.
Previous studies have established constitutive activation of Stat3 protein as one of the molecular changes required for… (More)
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Highly Cited
2004
Highly Cited
2004
XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy.
PURPOSE Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of DNA repair genes are associated… (More)
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Highly Cited
2004
Highly Cited
2004
Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells
The platinum compound oxaliplatin has been shown to be an effective chemotherapeutic agent for the treatment of colorectal cancer… (More)
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Highly Cited
2002
Highly Cited
2002
Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis.
PURPOSE To evaluate the relative effect of percent maximal cytoreductive surgery and other prognostic variables on survival among… (More)
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Highly Cited
1990
Highly Cited
1990
Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compounds.
Fifty-four patients with ovarian cancer who achieved a complete or partial remission with cisplatin or carboplatin were… (More)
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