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Pipemidic Acid

Known as: Piperamic Acid, Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-, Pipemidic Acid [Chemical/Ingredient] 
A pyridopyrimidine antibiotic derivative of piromidic acid with activity against gram-negative bacteria, as well as some gram-positive bacteria… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Anti-Bacterial AgentsAnti-Infective Agents, Urinary

Narrower (6)

DeblastonGalusanPalinPipemidate
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Determination of quinolones in plasma samples by capillary electrophoresis using solid-phase extraction.
2000
2000
A new method of quantification of pipemidic acid by capillary zone electrophoresis with end‐column amperometric detection
Capillary zone electrophoresis was employed for the determination of pipemidic acid using an end‐column amperometric detection… 
1996
1996
Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor.
Review
1996
Review
1996
From Chloroquine to Antineoplastic Drugs? The Story of Antibacterial Quinolones
Chemotherapy has not only proved valuable in treating many diseases but the history of discovery of some drugs makes exciting… 
Review
1992
Review
1992
The effects of quinolones on xanthine pharmacokinetics.
1991
1991
Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones
1989
1989
Interaction of quinolones with the theophylline metabolism in man: investigations with lomefloxacin and pipemidic acid.
The single-dose pharmacokinetics of theophylline alone and at the end of a five-day treatment period with a new difluorinated… 
Highly Cited
1987
Highly Cited
1987
In vitro and in vivo activity of NY-198, a new difluorinated quinolone
NY-198 [1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid hydrochloride] is a new… 
1987
1987
Ability of ciprofloxacin but not pipemidic acid to differentiate all three biovariants of Mycobacterium fortuitum from Mycobacterium chelonae
When tested against 312 clinical isolates of rapidly growing mycobacteria, the quinolone pipemidic acid correctly separated… 
Highly Cited
1978
Highly Cited
1978
Toxicological studies on pipemidic acid. V. Effect on diarthrodial joints of experimental animals.
Pipemidic acid (PPA) orally given in a dose of 100 mg/kg/day or more was found to cause lame gait in immature beagle dogs of… 
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