Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity

Known as: firefly luciferase activity, Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing), Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing) 
Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin. [EC:1.13.12.7, MetaCyc:1.13… (More)
National Institutes of Health

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2 relations
Luciferases, Firefly

Broader (1)

luciferin monooxygenase activity

Papers overview

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2007
2007
Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells.
Vascular Endothelial Growth Factor (VEGF) and its transcriptional regulator Hypoxia-inducible Factor 1 (HIF-1) play an important… (More)
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Highly Cited
2006
Highly Cited
2006
Design of expression vectors for RNA interference based on miRNAs and RNA splicing.
RNA interference (RNAi) mediates sequence-specific post-transcriptional gene silencing in many eukaryotes and is used for reverse… (More)
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Highly Cited
2003
Highly Cited
2003
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
Two genetic reporter systems were developed for multimodality reporter gene imaging of different molecular-genetic processes… (More)
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Highly Cited
2002
Highly Cited
2002
Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.
Mouse models of herpes simplex virus type 1 (HSV-1) infection provide significant insights into viral and host genes that… (More)
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Highly Cited
2001
Highly Cited
2001
Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
It was previously shown that CYP3A4 is induced in the human intestinal Caco-2 cell model by treatment with 1alpha,25-dihydroxy… (More)
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Highly Cited
1999
Highly Cited
1999
Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.
One of the mechanisms whereby glucose stimulates insulin gene transcription in pancreatic beta-cells involves activation of the… (More)
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Highly Cited
1997
Highly Cited
1997
Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence.
Osteocalcin is a hormonally regulated calcium-binding protein made almost exclusively by osteoblasts. In normal cells… (More)
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Highly Cited
1996
Highly Cited
1996
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.
BACKGROUND Firefly luciferase is a 62 kDa protein that catalyzes the production of light. In the presence of MgATP and molecular… (More)
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Highly Cited
1994
Highly Cited
1994
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.
Transforming growth factor-beta (TGF-beta) is a potent regulator of cellular differentiation, proliferation, migration, and… (More)
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Highly Cited
1985
Highly Cited
1985
Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.
A cDNA library was constructed from firefly (Photinus pyralis) lantern poly(A)+ RNA, using the Escherichia coli expression vector… (More)
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