Phospholipase C gamma

Known as: Phosphoinositide Phospholipase C-Gamma, PLCgamma, PLCG 
A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. It is structurally related to PHOSPHOLIPASE C… (More)

Topic mentions per year

Topic mentions per year

1989-2016
0204019892016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Signal transduction across cell membranes often involves the activation of both phosphatidylinositol (PI)-specific phospholipase… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Defects in the gene encoding Bruton's tyrosine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Upon ligand-induced tyrosine phosphorylation, the platelet-derived growth factor (PDGF) receptor (PDGFR) beta subunit associates… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
One of the beta 2-integrins found on hematopoietic cells is lymphocyte function-associated antigen 1 (LFA-1), a lymphocyte… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Hydrolysis by phospholipase C (PLC) of phosphatidylinositol 4,5-bisphosphate is a key mechanism by which many extracellular… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR; encoded by the flg gene) and… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Phospholipase C-gamma 1 (PLC-gamma 1), an isozyme of the phosphoinositide-specific phospholipase C family, which occupies a… (More)
Is this relevant?