FAQ

Phospholipase C gamma

Known as: Phosphoinositide Phospholipase C-Gamma, PLCgamma, PLCG 
A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. It is structurally related to PHOSPHOLIPASE C… (More)

Topic mentions per year

Topic mentions per year

1989-2016
0204019892016

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12 relations
In BloodPhospholipaseProcess of secretionadministration & dosage
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Narrower (2)

Phospholipase C gamma 2Phospholipase C gamma1

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Phospholipase C gamma
physiological aspects
Phospholipase
chemical synthesis
standards characteristics
Process of secretion

Papers overview

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Highly Cited
2000
Highly Cited
2000
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated… (More)
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Highly Cited
1999
Highly Cited
1999
Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance
Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays… (More)
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Highly Cited
1998
Highly Cited
1998
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate.
Signal transduction across cell membranes often involves the activation of both phosphatidylinositol (PI)-specific phospholipase… (More)
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Highly Cited
1996
Highly Cited
1996
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2
Defects in the gene encoding Bruton's tyrosine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which… (More)
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Highly Cited
1993
Highly Cited
1993
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.
Upon ligand-induced tyrosine phosphorylation, the platelet-derived growth factor (PDGF) receptor (PDGFR) beta subunit associates… (More)
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Highly Cited
1993
Highly Cited
1993
Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.
One of the beta 2-integrins found on hematopoietic cells is lymphocyte function-associated antigen 1 (LFA-1), a lymphocyte… (More)
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Highly Cited
1992
Highly Cited
1992
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Hydrolysis by phospholipase C (PLC) of phosphatidylinositol 4,5-bisphosphate is a key mechanism by which many extracellular… (More)
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Highly Cited
1991
Highly Cited
1991
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR; encoded by the flg gene) and… (More)
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Highly Cited
1991
Highly Cited
1991
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and… (More)
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Highly Cited
1990
Highly Cited
1990
Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.
Phospholipase C-gamma 1 (PLC-gamma 1), an isozyme of the phosphoinositide-specific phospholipase C family, which occupies a… (More)
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