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Phase I Clinical Trials

Known as: Trial Phase 1, phase i clinical trial, Clinical Trials, Phase I 
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects… 
National Institutes of Health

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CDISC SDTM Trial Phase TerminologyClinical Data Interchange Standards Consortium TerminologyClinical Trial, Phase IDouble-Blind Method

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Clinical Trials

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Microdosing Trials, Human

Papers overview

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2018
2018
Consideration of older patients for enrollment in phase 1 clinical trials: Exploring treatment related toxicities and outcomes.
2016
2016
Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with advanced solid tumors
SummaryPurpose This trial evaluated the maximum tolerated dose (MTD), safety, pharmacokinetics, and clinical effects of… 
2016
2016
Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma
Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a human-mouse chimeric anti… 
2016
2016
Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
Purpose When integrating molecularly targeted compounds in radiotherapy, synergistic effects of the systemic agent and radiation… 
2015
2015
Characteristics and outcomes for patients with advanced vaginal or vulvar cancer referred to a phase I clinical trials program: the MD Anderson cancer center experience
BackgroundEarly-stage vaginal and vulvar cancer can be cured. But outcomes of patients with metastatic disease are poor. Thus… 
2013
2013
The effect of CYP2C19 polymorphism on the safety, tolerability, and pharmacokinetics of tivantinib (ARQ 197): results from a phase I trial in advanced solid tumors.
BACKGROUND Tivantinib (formerly ARQ 197) is a selective inhibitor of c-Met mainly metabolized by CYP2C19. CYP2C19 is known for… 
2010
2010
Adjuvant chemoradiation for gastric cancer with infusional 5-fluorouracil and cisplatin: a phase I study.
OBJECTIVE This phase I study aimed to determine the maximal tolerated dose of cisplatin administered every 2 weeks with… 
2010
2010
The Experience of Older Patients With Cancer in Phase 1 Clinical Trials: A Qualitative Case Series
This article explores the experiences of older patients with cancer in phase 1 clinical trials. Conducting a case series of face… 
2000
2000
African green monkeys provide a useful nonhuman primate model for the study of human parainfluenza virus types-1, -2, and -3 infection.
1993
1993
Studies of safety, infectivity and immunogenicity of a new temperature-sensitive (ts) 51-1 strain of Salmonella typhi as a new live oral typhoid fever vaccine candidate.
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