Phase I Clinical Trials

Known as: Trial Phase 1, phase i clinical trial, Clinical Trials, Phase I 
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects… (More)
National Institutes of Health

Papers overview

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2017
2017
Under an NIH priority to identify new drugs to treat class B parasitic agents, we performed high-throughput screens, which… (More)
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2016
2016
UNLABELLED : Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage… (More)
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2016
2016
Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the expression of >30 oncogenes across multiple… (More)
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2015
2015
AFM13 is a bispecific, tetravalent chimeric antibody construct (TandAb) designed for the treatment of CD30-expressing… (More)
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2015
2015
To evaluate safety of TAS-102 administered twice daily (bid) on days 1–5 and 8–12 of a 4-week cycle, confirm feasibility of the… (More)
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2014
2014
BACKGROUND We report results of a phase I trial designed to estimate the maximum tolerated dose (MTD), describe dose-limiting… (More)
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2014
2014
Sepsis is a massive inflammatory response mediated by infection, characterized by oxidative stress, release of cytokines, and… (More)
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2011
2011
EACH YEAR, THOUSANDS OF INDIVIDUALS IN THE UNITED States enroll in phase 1 drug trials as healthy volunteers to earn money… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE The 14 amino acid sequence (aa(450-463)) TKDNNLLGRFELSG (TKD) of heat shock protein 70 (Hsp70) was identified as a tumor… (More)
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Highly Cited
1990
Highly Cited
1990
This paper looks at a new approach to the design and analysis of Phase 1 clinical trials in cancer. The basic idea and motivation… (More)
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