Pexastimogene-devacirepvec

Known as: JX-594, Thymidine Kinase-(-) Vaccinia-GM-CSF JX-594 Vaccine 
A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Efforts to selectively target and disrupt established tumor vasculature have largely failed to date. We hypothesized that a… (More)
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Highly Cited
2013
Highly Cited
2013
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in… (More)
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2013
2013
BackgroundThe biology of small cell ovarian carcinoma of the hypercalcemic type (SCCOHT), which is a rare and aggressive form of… (More)
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Highly Cited
2012
Highly Cited
2012
Oncolytic viruses are generally designed to be cancer selective on the basis of a single genetic mutation. JX-594 is a thymidine… (More)
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Highly Cited
2011
Highly Cited
2011
The efficacy and safety of biological molecules in cancer therapy, such as peptides and small interfering RNAs (siRNAs), could be… (More)
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Review
2010
Review
2010
Chemotherapy remains a common mode of anticancer treatment even though in most cancer indications the therapeutic approach is not… (More)
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2010
2010
The purpose of this study was to investigate the oncolytic potential of the recombinant, granulocyte macrophage colony… (More)
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Review
2009
Review
2009
JX-594 is a replication-competent Wyeth strain vaccinia virus that was genetically modified to inactive the endogenous thymidine… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND JX-594 is a targeted oncolytic poxvirus designed to selectively replicate in and destroy cancer cells with cell-cycle… (More)
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Highly Cited
2006
Highly Cited
2006
Targeted oncolytic viruses and immunostimulatory therapeutics are being developed as novel cancer treatment platforms. These… (More)
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