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Objective: To measure dexamethasone concentrations in the plasma and perilymph of the human ear after intravenous (IV) and… Expand used to describe multiple sensations (vertigo, presyncope, disequilibrium), each having numerous etiologies. It is often… Expand Purpose: Our goal is to develop a novel drug delivery system that can potentially improve clinical outcomes compared to current… Expand Measurements of drug levels in the fluids of the inner ear are required to establish kinetic parameters and to determine the… Expand Acoustic overstimulation is one of the major causes of hearing loss. Glutamate is the most likely candidate neurotransmitter for… Expand The concentration of adenosine 5'-triphosphate (ATP) in endolymph (EL), perilymph (PL) and cerebrospinal fluid (CSF), collected… Expand Establishing the diagnosis of perilymph fistula remains a dilemma. At this time, identification of an active perilymph fistula… Expand After intraperitoneal administration of salicylate in anesthetized rats and guinea pigs, we found that salicylate levels in… Expand The immunoglobulin composition of perilymph (PL) was measured using electroimmunodiffusion, and transfer of serum antibodies to… Expand Between July 1976 and August 1979, 14 patients underwent surgical repair of a traumatic tympanic membrane perforation. Of these… Expand