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Perforin Deficiency

A condition of decreased or absent presence of perforin. Deficiency of this protein is associated with T-cell lymphoblastic lymphoma, aplastic anemia… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
After stimulation of antigen-specific T cells, dendritic cell (DCs) are susceptible to killing by these activated T cells that… Expand
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Review
2010
Review
2010
Type 1 diabetes results from autoimmune destruction of pancreatic β-cells by CD8+ T cells. The requirement for CD8+ T cells… Expand
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Highly Cited
2010
Highly Cited
2010
Granzyme B (GZMB) is a serine protease that is abundantly expressed in advanced human atherosclerotic lesions and may contribute… Expand
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2010
2010
Background: Patients with inflammatory bowel disease (IBD) have a markedly increased risk to develop colon cancer, but there are… Expand
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2007
2007
The concept of tumor immune surveillance has been supported by several recent studies in mice which show that immune effector… Expand
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Highly Cited
2005
Highly Cited
2005
Perforin mutations have been demonstrated in a proportion of patients diagnosed with the familial form of hemophagocytic… Expand
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2005
2005
The familial form of haemophagocytic lymphohistiocytosis (HLH) is a fatal disease, with allogeneic stem cell transplantation (SCT… Expand
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Highly Cited
2003
Highly Cited
2003
Secretion of cytolytic granules content at the immunological synapse is a highly regulated process essential for lymphocyte… Expand
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Highly Cited
2002
Highly Cited
2002
Summary. Familial haemophagocytic lymphohistiocytosis (FHL), an inherited form of haemophagocytic lymphohistiocytosis (HLH… Expand
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Highly Cited
1999
Highly Cited
1999
IL‐12 exerts a potent anti‐tumor effect, which is possibly mediated by multiple mechanisms including activation of NK and NKT… Expand
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