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Pathologic Mutagenesis

Known as: Mutagenic Process, Mutagenic Process, Pathologic 
Any event, process, or activity that produces a deleterious alteration of DNA. (NCI)
National Institutes of Health

Papers overview

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2015
2015
Aristolochic acid (AA) is a potent dietary cytotoxin and carcinogen, and an established etiological agent underlying severe human… Expand
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2013
2013
Replication fork pausing drives genome instability, because any loss of paused replisome activity creates a requirement for… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Translesion synthesis in mammalian cells is achieved by sequential actions of insertion and extension polymerases… Expand
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Highly Cited
2002
Highly Cited
2002
Asbestos is an important environmental carcinogen in the United States and remains the primary occupational concern in many… Expand
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Highly Cited
1999
Highly Cited
1999
The Escherichia coli umuDC operon is induced in response to replication-blocking DNA lesions as part of the SOS response. UmuD… Expand
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1999
1999
The formation of cyclobutane pyrimidine dimers (CPD) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) was investigated in… Expand
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1999
1999
The pattern of somatic mutations of shark and frog Ig is distinct from somatic hypermutation of Ig in mammals in that there is a… Expand
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Highly Cited
1996
Highly Cited
1996
Reversion of a lac- frameshift allele carried on an F' episome in Escherichia coli occurs at a high rate when the cells are… Expand
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Highly Cited
1991
Highly Cited
1991
The p53 gene has been implicated as a tumor-suppressor gene whose disruption is involved in the pathogenesis of common human… Expand
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1990
1990
Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-T transition… Expand
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