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PXXP Motif

Known as: PXXP Domain 
The SH3 domain, often seen in signaling pathway proteins, frequently binds to a conserved PXXP Motif usually found in proline-rich regions of target… 
National Institutes of Health

Related topics

Related topics

1 relation
STAMBP protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Molecular design and optimization of hepatic cancer SLP76‐derived PLCγ1 SH3‐binding peptide with the systematic N‐substitution of peptide PXXP motif
The phospholipase Cγ1 (PLCγ1) is essential for T‐cell signaling and activation in hepatic cancer immune response, which has a… 
2011
2011
Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a
The guanine-nucleotide exchange factor (GEF) RalGPS1a activates small GTPase Ral proteins such as RalA and RalB by stimulating… 
2008
2008
Experimental Studies of N-methyl-D- aspartate Receptor NR3 Subunits
This thesis focuses on the NR3A and NR3B subunits of the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). Functional… 
2007
2007
A ROLE FOR P 63 IN THE REGULATION OF CELL CYCLE PROGRESSION AND CELL DEATH by
p63, a member of the p53 family of transcription factors, is known to be involved in epithelial development. However, its role in… 
2006
2006
Possible role of a PXXP central hinge in the antibacterial activity and membrane interaction of PMAP-23, a member of cathelicidin family.
Cathelicidins are essential components of the innate immune system of mammals, providing them a weapon against microbial invasion… 
Highly Cited
2000
Highly Cited
2000
The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure, Acting Downstream of Distinct Signals
ABSTRACT We have previously shown that the Ste20 kinase encoded bymisshapen (msn) functions upstream of the c-Jun N-terminal… 
1998
1998
Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
The Src homology 3 (SH3) domains are a modular structure of about 60 amino acid residues found in many proteins important in… 
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