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PX-866
Known as:
PI3K Inhibitor PX-866
, acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha 12-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester
A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential…
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National Institutes of Health
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2 relations
Broader (1)
Gonanes
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CaMKK 2 activates Akt in ovarian cancer cells 1 Akt Activation by Ca 2 + / calmodulin-dependent protein Kinase Kinase 2 ( CaMKK 2 ) in Ovarian Cancer Cells
A. Gocher
,
G. Azabdaftari
,
+4 authors
A. Edelman
2017
Corpus ID: 207773007
Hyperactivation of Akt is associated with oncogenic changes in the growth, survival and chemoresistance of cancer cells. The PI3K…
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2010
2010
Cardiovascular , Pulmonary and Renal Pathology Inhibition of PI 3 K by PX-866 Prevents Transforming Growth Factor-– Induced Pulmonary Fibrosis
T. L. Cras
,
T. Korfhagen
,
+5 authors
W. Hardie
2010
Corpus ID: 207885781
Transforming growth factor(TGF ) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with…
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2009
2009
Abstract #3716: Preclinical toxicology comparing intermittent and continuous administration of PX-866, a novel irreversible phosphoinositide-3-kinase (PI-3K) inhibitor
J. Millard
,
L. Pestano
,
Jennifer A. Johnson
,
Kirk Dl
2009
Corpus ID: 59344680
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO PX-866 is an irreversible, pan-inhibitor of PI-3K with potent oral antitumor…
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