Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 236,387,571 papers from all fields of science
Search
Sign In
Create Free Account
PX-866
Known as:
PI3K Inhibitor PX-866
, acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha 12-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester
A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
2 relations
Broader (1)
Gonanes
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CaMKK 2 activates Akt in ovarian cancer cells 1 Akt Activation by Ca 2 + / calmodulin-dependent protein Kinase Kinase 2 ( CaMKK 2 ) in Ovarian Cancer Cells
A. Gocher
,
G. Azabdaftari
,
+4 authors
A. Edelman
2017
Corpus ID: 207773007
Hyperactivation of Akt is associated with oncogenic changes in the growth, survival and chemoresistance of cancer cells. The PI3K…
Expand
2010
2010
Cardiovascular , Pulmonary and Renal Pathology Inhibition of PI 3 K by PX-866 Prevents Transforming Growth Factor-– Induced Pulmonary Fibrosis
T. L. Cras
,
T. Korfhagen
,
+5 authors
W. Hardie
2010
Corpus ID: 207885781
Transforming growth factor(TGF ) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with…
Expand
2009
2009
Abstract #3716: Preclinical toxicology comparing intermittent and continuous administration of PX-866, a novel irreversible phosphoinositide-3-kinase (PI-3K) inhibitor
J. Millard
,
L. Pestano
,
Jennifer A. Johnson
,
Kirk Dl
2009
Corpus ID: 59344680
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO PX-866 is an irreversible, pan-inhibitor of PI-3K with potent oral antitumor…
Expand