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Significance NMDA receptors (NMDARs) are principal regulators of synaptic signaling in the brain. Modulation of NMDARs’ function… Expand BackgroundSustained changes in network activity cause homeostatic synaptic plasticity in part by altering the postsynaptic… Expand Significance In neurons, STEP61 (striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the… Expand The STriatal‐Enriched protein tyrosine Phosphatase 61 (STEP61) inhibits the activity of the tyrosine kinase Fyn and… Expand It is reported that the amyloid-β protein (Aβ)-induced impairments in synaptic plasticity coincide with memory decline and… Expand Glutamatergic signaling through N-methyl-D-aspartate receptors (NMDARs) is required for synaptic plasticity. Disruptions in… Expand While stressful life events confer increased risk for the development of psychopathology, most individuals experiencing adversity… Expand Amyloid β (Aβ) is involved in the etiology of Alzheimer's disease (AD) and may contribute to cognitive deficits by increasing… Expand Striatal enriched phosphatase (STEP) is a family of protein tyrosine phosphatases enriched within the CNS. A member of this… Expand The STEP family of protein tyrosine phosphatases is highly enriched within the CNS. Members of this family are alternatively… Expand