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PTPN5 gene

Known as: PTPSTEP, STEP, striatal-enriched protein tyrosine phosphatase 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61
Significance NMDA receptors (NMDARs) are principal regulators of synaptic signaling in the brain. Modulation of NMDARs’ function… 
2015
2015
Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity
BackgroundSustained changes in network activity cause homeostatic synaptic plasticity in part by altering the postsynaptic… 
2014
2014
Inhibition of striatal‐enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption
The STriatal‐Enriched protein tyrosine Phosphatase 61 (STEP61) inhibits the activity of the tyrosine kinase Fyn and… 
2014
2014
Regulation of Tyrosine Phosphatase STEP61 by Protein Kinase A during Motor Skill Learning in Mice
Recently, striatal-enriched protein tyrosine phosphatase (STEP) and its upstream regulator protein kinase A (PKA) have been… 
Highly Cited
2013
Highly Cited
2013
Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3
2013
2013
Tyrosine phosphatase STEP61 negatively regulates amyloid β‐mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors
Striatal‐enriched phosphatase 61 (STEP61) plays an essential role in synaptic plasticity and has recently been implicated in… 
2011
2011
Functional Adaptation of the N-Methyl-d-aspartate Receptor to Inhibition by Ethanol Is Modulated by Striatal-Enriched Protein Tyrosine Phosphatase and p38 Mitogen-Activated Protein Kinase
The hippocampal N-methyl-d-aspartate receptor (NMDAR) activity plays important roles in cognition and is a major substrate for… 
2011
2011
Oxidative stress‐induced oligomerization inhibits the activity of the non‐receptor tyrosine phosphatase STEP61
J. Neurochem. (2011) 116, 1097–1111. 
1999
1999
Calcium‐Dependent Cleavage of Striatal Enriched Tyrosine Phosphatase (STEP)
Striatal enriched phosphatase (STEP) is a family of protein tyrosine phosphatases enriched within the CNS. A member of this… 
Highly Cited
1996
Highly Cited
1996
STEP61: A Member of a Family of Brain-Enriched PTPs Is Localized to the Endoplasmic Reticulum
The STEP family of protein tyrosine phosphatases is highly enriched within the CNS. Members of this family are alternatively… 
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