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PTPN22 protein, human

Known as: PTPN8 protein, human, PTPN22, LyP 
Tyrosine-protein phosphatase non-receptor type 22 (807 aa, ~92 kDa) is encoded by the human PTPN22 gene. This protein is involved in both protein… 
National Institutes of Health

Related topics

Related topics

21 relations
B-LymphocytesCytoplasmDephosphorylationEnzyme Gene

Broader (1)

protein-tyrosine phosphatase Lyp

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Inflammasomes form as the result of the intracellular presence of danger-associated molecular patterns and mediate the release of… 
Highly Cited
2011
Highly Cited
2011
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The… 
Highly Cited
2011
Highly Cited
2011
The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
A variant of the PTPN22-encoded Lyp phosphatase (Lyp620W) confers risk for autoimmune disease, but the mechanisms underlying this… 
Review
2010
Review
2010
Genetic susceptibility to systemic lupus erythematosus in the genomic era
Our understanding of the genetic basis of systemic lupus erythematosus (SLE) has been rapidly advanced using large-scale, case… 
Highly Cited
2009
Highly Cited
2009
Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling1
PTPN22 is a gene encoding the protein tyrosine phosphatase Lyp. A missense mutation changing residue 1858 from cytosine to… 
Review
2007
Review
2007
Protein tyrosine phosphatase PTPN22 in human autoimmunity
The discovery that a single-nucleotide polymorphism (SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is… 
Highly Cited
2006
Highly Cited
2006
Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22*
Stimulation of mature T cells activates a downstream signaling cascade involving temporally and spatially regulated… 
Highly Cited
2005
Highly Cited
2005
The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status
We have recently described the association between rheumatoid arthritis and a coding single-nucleotide polymorphism in the… 
Highly Cited
2005
Highly Cited
2005
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
OBJECTIVE Analyses of families with multiple autoimmune disorders have revealed a functional polymorphism, 620W, in the… 
Highly Cited
1999
Highly Cited
1999
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.
Protein tyrosine phosphatases act in conjunction with protein kinases to regulate the tyrosine phosphorylation events that… 
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