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PTGDR2 gene

Known as: GPR44, CD294, PTGDR2 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist
The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) is a G protein-coupled receptor that… 
Review
2010
Review
2010
Novel CRTH2 antagonists: a review of patents from 2006 to 2009
Importance of the field: The receptor CRTH2 (also known as DP2) is an important mediator of the inflammatory effects of… 
2009
2009
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
2007
2007
A paracrine role for chemoattractant receptor‐homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes
Summary Activation of human CRTH2+ CD4+ T helper type 2 (Th2) cells with anti‐CD3/anti‐CD28 led to time‐dependent production of… 
Review
2006
Review
2006
Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor.
It is known that thromboxane A2 (TXA2) contributes to various diseases such as bronchial asthma, ischemic heart disease… 
Highly Cited
2006
Highly Cited
2006
A dominant role for chemoattractant receptor‐homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell…
Human cultured mast cells, immunologically activated with immunoglobuin E (IgE)/anti‐IgE, released a factor(s) that promoted… 
Review
2006
Review
2006
Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation.
The involvement of prostaglandin D(2) (PGD(2)) in inflammatory diseases like allergy and asthma is well established, thus… 
Highly Cited
2005
Highly Cited
2005
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.
Ramatroban, a thromboxane A(2) receptor (TP) antagonist with clinical efficacy in asthma and allergic rhinitis, was recently… 
2005
2005
CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.
2003
2003
Differential expression of CCR5 and CRTH2 on infiltrated cells in colonic mucosa of patients with ulcerative colitis
Background and Aim:  The pathogenesis of ulcerative colitis (UC) is unclear, but abnormal infiltration of T lymphocytes in the… 
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