PTCH1 gene

Known as: PTCH, BCNS, PTCH1 
This gene is involved in tumor suppression and mutations in this gene have been associated with several cancers and cancer related diseases.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that… (More)
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Highly Cited
2012
Highly Cited
2012
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common… (More)
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Highly Cited
2009
Highly Cited
2009
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is… (More)
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Review
2009
Review
2009
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma, basal cell carcinoma, lung cancer, esophageal cancer… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Basal cell carcinoma (BCC) of the skin is the most common human cancer. The genetic alterations underlying BCC… (More)
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Highly Cited
2004
Highly Cited
2004
The PTCH1 tumor suppressor gene encodes a receptor for secreted hedgehog (HH) ligands and is important for proper proliferation… (More)
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Review
2002
Review
2002
Immunocytochemical studies of the expression of PCNA, Ki67 and p53 protein have been done by different groups on sporadic… (More)
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2002
2002
The PTCH1 gene is a human tumour suppressor gene frequently mutated in basal cell carcinoma (BCC) and several other tumour types… (More)
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Highly Cited
2000
Highly Cited
2000
Inactivation of the PTCH tumor suppressor gene occurs in a subset of sporadic medulloblastomas, suggesting that alterations in… (More)
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Highly Cited
1998
Highly Cited
1998
The signaling molecule encoded by Sonic hedgehog (shh) participates in the patterning of several embryonic structures including… (More)
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