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PTCH1 gene

Known as: PTCH, BCNS, PTCH1 
This gene is involved in tumor suppression and mutations in this gene have been associated with several cancers and cancer related diseases.
National Institutes of Health

Related topics

Related topics

35 relations
Anal margin basal cell carcinomaBasal Cell Nevus SyndromeBasal cell carcinomaBasal cell carcinoma, infundibulocystic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.
The Patched 1 (Ptch1) receptor has a pivotal role in inhibiting the activity of the Hedgehog (Hh) pathway and is therefore… 
2012
2012
Activation of the Sonic Hedgehog Pathway and Its Prognostic Impact in Patients with Gastric Cancer
Background: The sonic hedgehog (SHH) signaling pathway is critical in fetal organogenesis. Activation of the SHH pathway has been… 
2010
2010
Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer
Activation of the hedgehog (HH) pathway plays a critical role in the development and continued growth of pancreatic… 
2010
2010
Hedgehog signaling regulates proliferation of prostate cancer cells via stathmin1
Hedgehog (Hh) signaling is an essential pathway in embryonic development of prostate. Hh also plays roles in the proliferation of… 
2009
2009
Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation
Systemic hormones and local growth factor-mediated tissue interactions are essential for mammary gland development. Using… 
2007
2007
Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling
Patched1 (PTCH1) is one of the key molecules involved in the Hedgehog (HH) signaling pathway and acts as the receptor of HH… 
2005
2005
A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing.
Mutations of the Sonic hedgehog (SHH) receptor, Patched1 (PTCH1), have been identified in a variety of tumors. PTCH1 is usually… 
2004
2004
A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions
2003
2003
Interstitial deletion of chromosome 9, int del(9)(9q22.31-q31.2), including the genes causing multiple basal cell nevus syndrome and Robinow/brachydactyly 1 syndrome
We report a child with a de novo interstitial deletion, 46,XY, int del(9)(9q22.31-q31.2). Cytogenetic and molecular analysis… 
2002
2002
Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo.
Heparan sulphate proteoglycans have been implicated in the binding and presentation of several growth factors to their receptors… 
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