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PRT4165

 
National Institutes of Health

Papers overview

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2020
2020
Inhibition of RING1B alters lineage specificity in human embryonic stem cells
Polycomb group (PcG) proteins are histone modifiers which are known to perform transcriptional repression and have been shown to… Expand
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2017
2017
BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells.
BACKGROUND/AIM B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is up-regulated in several cancers… Expand
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2015
2015
A mechanistic study of the Polycomb PR-DUB complex
BAP1 is as a tumor suppressor that associates to a variety of protein partners, thereby limiting the comprehension of its… Expand
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Highly Cited
2013
Highly Cited
2013
A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks*
Background: DNA damage-induced ubiquitylation is important in regulating the DNA damage response. Results: PRT4165 inhibits… Expand
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