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PRI-2191

National Institutes of Health

Papers overview

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2016
2016
The Effect of Analogues of 1α,25-Dihydroxyvitamin D2 on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil
This study aimed to evaluate the capacity of hypocalcemic analogues of 1α,25-dihydroxyvitamin D2 (1,25D2) and 1α,25… 
2015
2015
Vitamin D Analogs Potentiate the Antitumor Effect of Imatinib Mesylate in a Human A549 Lung Tumor Model
In previous papers, we presented data on studies on the anticancer activity of the vitamin D3 analogs, named PRI-2191 and PRI… 
2012
2012
The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells
Imatinib mesylate (Gleevec, STI571) is a specific inhibitor of the Bcr/Abl fusion tyrosine kinase that exhibits potent… 
2010
2010
Antitumor properties of (5E,7E) analogs of vitamin D3
2008
2008
The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on alphavbeta3 integrin expression in cancer cell lines.
Integrins are cell-surface receptors engaged in important cancer invasion processes, such as adhesion, migration, proliferation… 
2007
2007
The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.
New vitamin D analogs are interesting candidates for anticancer treatment, including squamous cell carcinomas (SCCs), especially… 
2005
2005
Side-chain-modified analogs of calcitriol cause resistance of human HL-60 promyelocytic leukemia cells to drug-induced apoptosis
2005
2005
Correlation between VDR expression and antiproliferative activity of vitamin D3 compounds in combination with cytostatics.
Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Its biological activity is mediated by the… 
2005
2005
Effects of PRI-2191—A low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat
1999
1999
Antiproliferative activity in vitro of side-chain analogues of calcitriol against various human normal and cancer cell lines.
The antiproliferative in vitro activity of side-chain modified analogues of 1,25-dihydroxyvitamin D3 was examined in order to… 
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