PR-619
National Institutes of Health
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2,6-Diaminopyridine-3,5-bis(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been…
In epithelia, the intermediate conductance, Ca2+-activated K+ channel (KCa3.1) is targeted to the basolateral membrane (BLM…
Mycobacterium bovis is the causative agent of tuberculosis in cattle. Infection of macrophages with M. bovis leads to the…
Platelet FcγRIIA is central to the pathophysiology of immune-mediated thrombocytopenia and thrombosis syndromes, such as heparin…
Protein aggregate formation may be the result of an impairment of the protein quality control system, e.g., the ubiquitin…
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC
TNF-related apoptosis-inducing ligand (TRAIL…
Ubiquitination plays a key role in protein degradation and signal transduction. Ubiquitin is a small protein modifier that is…