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POLG2 gene

Known as: POLYMERASE, DNA, GAMMA-2, HP55, polymerase (DNA) gamma 2, accessory subunit 
 
National Institutes of Health

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POLG gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance.
Mammalian mitochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol γ comprised of a single catalytic subunit, encoded by… Expand
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2013
2013
Preparation, characterization, and evaluation in vivo of Ins-SiO₂-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin.
Insulin is the most effective and durable drug in the treatment of advanced stage diabetes. However, oral delivering insulin was… Expand
Highly Cited
2012
Highly Cited
2012
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for… Expand
2012
2012
Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery
The aim of the present study was to develop the PLGA/HP55 nanoparticles with improved hypoglycemic effect for oral insulin… Expand
Highly Cited
2011
Highly Cited
2011
Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
Defects in mitochondrial DNA (mtDNA) maintenance comprise an expanding repertoire of polymorphic diseases caused, in part, by… Expand
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2010
2010
Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2
Polymerase gamma 1 (POLG) mutations are a frequent cause of both autosomal dominant and recessive complex neurological phenotypes… Expand
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Highly Cited
2008
Highly Cited
2008
Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo
The Myc oncoprotein is a transcription factor involved in a variety of human cancers. Overexpression of Myc is associated with… Expand
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Highly Cited
2006
Highly Cited
2006
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
DNA polymerase gamma (pol gamma ) is required to maintain the genetic integrity of the 16,569-bp human mitochondrial genome… Expand
Highly Cited
2004
Highly Cited
2004
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
The pH-sensitive cyclosporine A (CyA) nanoparticles were prepared by the solvent displacement method with enteric dissolved… Expand
Highly Cited
1999
Highly Cited
1999
The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance*
Human DNA polymerase γ is composed of a 140-kDa catalytic subunit and a smaller accessory protein variously reported to be 43–54… Expand
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