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POLG2 gene
Known as:
POLYMERASE, DNA, GAMMA-2
, HP55
, polymerase (DNA) gamma 2, accessory subunit
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National Institutes of Health
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Related topics
Related topics
1 relation
POLG gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance.
Margaret M. Humble
,
M. J. Young
,
J. Foley
,
A. Pandiri
,
G. Travlos
,
W. Copeland
Human molecular genetics
2013
Corpus ID: 16124759
Mammalian mitochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol γ comprised of a single catalytic subunit, encoded by…
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2013
2013
Preparation, characterization, and evaluation in vivo of Ins-SiO₂-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin.
Xiuhua Zhao
,
Chang Shan
,
+5 authors
R. Li
International journal of pharmaceutics
2013
Corpus ID: 23284985
Insulin is the most effective and durable drug in the treatment of advanced stage diabetes. However, oral delivering insulin was…
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Highly Cited
2012
Highly Cited
2012
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
Z. M. Wu
,
Liying Zhou
,
+5 authors
L. Zhang
International journal of pharmaceutics
2012
Corpus ID: 36697687
In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for…
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2012
2012
Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery
Z. M. Wu
,
Li Ling
,
+5 authors
L. Zhang
Nanoscale Research Letters
2012
Corpus ID: 792850
The aim of the present study was to develop the PLGA/HP55 nanoparticles with improved hypoglycemic effect for oral insulin…
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Highly Cited
2011
Highly Cited
2011
Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
M. J. Young
,
M. Longley
,
Fang-yuan Li
,
R. Kasiviswanathan
,
L. Wong
,
W. Copeland
Human molecular genetics
2011
Corpus ID: 13987415
Defects in mitochondrial DNA (mtDNA) maintenance comprise an expanding repertoire of polymorphic diseases caused, in part, by…
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2010
2010
Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2
M. Walter
,
B. Czermin
,
+10 authors
R. Horvath
Journal of Neurology
2010
Corpus ID: 25552801
Polymerase gamma 1 (POLG) mutations are a frequent cause of both autosomal dominant and recessive complex neurological phenotypes…
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Highly Cited
2008
Highly Cited
2008
Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo
Jonghwan Kim
,
J. Lee
,
V. R. Iyer
PloS one
2008
Corpus ID: 10912785
The Myc oncoprotein is a transcription factor involved in a variety of human cancers. Overexpression of Myc is associated with…
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Highly Cited
2006
Highly Cited
2006
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
M. Longley
,
S. Clark
,
+7 authors
P. Chinnery
American journal of human genetics
2006
Corpus ID: 13929066
DNA polymerase gamma (pol gamma ) is required to maintain the genetic integrity of the 16,569-bp human mitochondrial genome…
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Highly Cited
2004
Highly Cited
2004
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
Xue-qing Wang
,
Jun-dong Dai
,
+4 authors
Q. Zhang
Journal of controlled release : official journal…
2004
Corpus ID: 25754727
The pH-sensitive cyclosporine A (CyA) nanoparticles were prepared by the solvent displacement method with enteric dissolved…
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Highly Cited
1999
Highly Cited
1999
The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance*
S. Lim
,
M. Longley
,
W. Copeland
The Journal of Biological Chemistry
1999
Corpus ID: 9974258
Human DNA polymerase γ is composed of a 140-kDa catalytic subunit and a smaller accessory protein variously reported to be 43–54…
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