POLG2 gene

Known as: POLYMERASE, DNA, GAMMA-2, HP55, polymerase (DNA) gamma 2, accessory subunit 
 
National Institutes of Health

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POLG gene

Papers overview

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2015
2015
Maternal age and in vitro culture affect mitochondrial number and function in equine oocytes and embryos.
Advanced maternal age and in vitro embryo production (IVP) predispose to pregnancy loss in horses. We investigated whether mare… Expand
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2015
2015
Matrix effects in nilotinib formulations with pH-responsive polymer produced by carbon dioxide-mediated precipitation.
Factors determining the pH-controlled dissolution kinetics of nilotinib formulations with the pH-titrable polymer hydroxypropyl… Expand
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2013
2013
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance.
Mammalian mitochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol γ comprised of a single catalytic subunit, encoded by… Expand
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2012
2012
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for… Expand
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2011
2011
Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
Defects in mitochondrial DNA (mtDNA) maintenance comprise an expanding repertoire of polymorphic diseases caused, in part, by… Expand
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Highly Cited
2009
Highly Cited
2009
A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.
Autosomal-dominant progressive external ophthalmoplegia (adPEO) is a mitochondrial disorder that is characterized by accumulation… Expand
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Highly Cited
2008
Highly Cited
2008
Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo
The Myc oncoprotein is a transcription factor involved in a variety of human cancers. Overexpression of Myc is associated with… Expand
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Highly Cited
2006
Highly Cited
2006
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
DNA polymerase gamma (pol gamma ) is required to maintain the genetic integrity of the 16,569-bp human mitochondrial genome… Expand
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2004
2004
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
The pH-sensitive cyclosporine A (CyA) nanoparticles were prepared by the solvent displacement method with enteric dissolved… Expand
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Highly Cited
1999
Highly Cited
1999
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance.
Human DNA polymerase gamma is composed of a 140-kDa catalytic subunit and a smaller accessory protein variously reported to be 43… Expand
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