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POFUT1 gene

Known as: GDP-fucose protein O-fucosyltransferase 1, OFUCT1, FUT12 
National Institutes of Health

Related topics

Related topics

1 relation
POFUT2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
RETRACTED ARTICLE: Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma
Caveolin-1 (Cav-1) is an important structural protein of caveolae and plays an oncogene-like role by influencing protein… 
Highly Cited
2017
Highly Cited
2017
O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking
Glycosylation in the endoplasmic reticulum (ER) is closely associated with protein folding and quality control. We recently… 
2017
2017
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning… 
2017
2017
Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
2016
2016
Mutations in POGLUT1 in Galli–Galli/Dowling–Degos disease
The group of reticulate pigmentary disorders includes the rare autosomal dominant Dowling-Degos disease (DDD) and Galli-Galli… 
2014
2014
O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function
Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in… 
2014
2014
LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal–maternal interface
Trophoblast cell migration and invasion are crucial for the establishment of a successful pregnancy. Protein O… 
Review
2008
Review
2008
Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds… 
Highly Cited
2007
Highly Cited
2007
Focused microarray analysis of glyco‐gene expression in human glioblastomas
Altered glycosylation has been linked to cancer cell metastasis and invasivity. We have previously shown that expressing a… 
Highly Cited
2003
Highly Cited
2003
Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe*
Notch receptors are glycoproteins that mediate a wide range of developmental processes. Notch is modified in its epidermal growth… 
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