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PNU-214565

Known as: C242Fab-SEA Immunotoxin 
A recombinant fusion protein of the bacterial superantigen Staphylococcal enterotoxin A (SEA) and the variable Fab fragment of the C242 monoclonal… Expand
National Institutes of Health

Papers overview

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2000
2000
To develop a T-cell-based therapy for carcinomas, the superantigen staphylococcal enterotoxin A (SEA) was supplied with tumor… Expand
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1998
1998
Antibody-directed, superantigen-induced cytotoxicity has been shown to have potent in vitro and in vivo antitumor effects in… Expand
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Review
1998
Review
1998
Two Phase I clinical trials have been conducted using PNU-214565, a recombinant fusion protein of C242Fab and staphylococcal… Expand
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Highly Cited
1997
Highly Cited
1997
PURPOSE To establish the maximum-tolerated dose (MTD) and define the toxicities of a single-dose infusion of PNU-214565, a… Expand
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