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PNU 120596

Known as: PNU-120596, PNU120596 
National Institutes of Health

Papers overview

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2018
2018
Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of α7 Nicotinic Receptor Intracellular Calcium
The pharmacological targeting of the α7 nicotinic acetylcholine receptor (α7) is a promising strategy in the development of new… 
Highly Cited
2016
Highly Cited
2016
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
2016
2016
The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors
Highly Cited
2015
Highly Cited
2015
Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats
Highly Cited
2013
Highly Cited
2013
Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models
2013
2013
Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist
Highly Cited
2012
Highly Cited
2012
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats
The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia… 
Highly Cited
2011
Highly Cited
2011
Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization
Review
2011
Review
2011
3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels
Highly Cited
2009
Highly Cited
2009
Glutamate–Dopamine Crosstalk in the Rat Prefrontal Cortex is Modulated by Alpha7 Nicotinic Receptors and Potentiated by PNU-120596
The aim of this study was to explore the modulation by α7 nicotinic receptors (nAChRs) of dopamine and glutamate release in the… 
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