PNPLA3 gene

Known as: ADPN, dJ796I17.1, PHOSPHOLIPASE A2, CALCIUM-INDEPENDENT, EPSILON 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
UNLABELLED A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is… (More)
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Highly Cited
2012
Highly Cited
2012
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to… (More)
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Highly Cited
2011
Highly Cited
2011
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.
PNPLA3 (adiponutrin, calcium-independent phospholipase A(2) epsilon [iPLA(2)ε]) is an adipose-enriched, nutritionally regulated… (More)
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Highly Cited
2011
Highly Cited
2011
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.
BACKGROUND & AIMS A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin… (More)
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Highly Cited
2010
Highly Cited
2010
A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis*
Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously… (More)
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Highly Cited
2010
Highly Cited
2010
A feed-forward loop amplifies nutritional regulation of PNPLA3.
The upsurge in prevalence of obesity has spawned an epidemic of nonalcoholic fatty liver disease (NAFLD). Previously, we… (More)
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Highly Cited
2010
Highly Cited
2010
Variant in PNPLA3 is associated with alcoholic liver disease
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and… (More)
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Highly Cited
2010
Highly Cited
2010
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.
UNLABELLED Single nucleotide polymorphisms (SNPs) near 7 loci have been associated with liver function tests or with liver… (More)
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Highly Cited
2009
Highly Cited
2009
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with… (More)
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Highly Cited
2008
Highly Cited
2008
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among… (More)
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