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PLX 4720

Known as: PLX-4720, PLX4720 
National Institutes of Health

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2 relations

Broader (2)

IndolesSulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Drug nanocarriers for cancer chemotherapy based on microemulsions: The case of Vemurafenib analog PLX4720.
2016
2016
VEGF blockade enhances the antitumor effect of BRAFV 600E inhibition
The development of resistance remains a major obstacle to long‐term disease control in cancer patients treated with targeted… 
2015
2015
Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAF(V600E) mutant thyroid cancer cells in 2D and 3D culture.
2014
2014
Beneficial Effects of RAF Inhibitor in Mutant BRAF Splice Variant–Expressing Melanoma
Resistance to RAF inhibitors such as vemurafenib and dabrafenib is a major clinical problem in the treatment of melanoma… 
2014
2014
BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
Purpose: Small molecule inhibitors of the mitogen-activated protein kinase (MAPK) pathway, such as sorafenib, represent novel… 
2013
2013
Companion Diagnostics and Cancer Biomarkers BRAF V 600 E Is a Determinant of Sensitivity to Proteasome Inhibitors
A critical step toward defining tailored therapy in patients with cancer is the identification of genetic interactions that may… 
2013
2013
Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-Lineage Cells Resistant to PLX4720
Mutational activation of BRAF leading to expression of the BRAFV600E oncoprotein was recently identified in a high percentage of… 
2012
2012
Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research.
Review
2011
Review
2011
BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression.
Papillary thyroid cancer (PTC) rates continue to increase in the United States and Europe, and, although most patients do well… 
2010
2010
Induction of apoptosis in human melanoma by the BRAF inhibitor PLX4720: The key to therapeutic success?
8559 Background: A high proportion of Patients with metastatic melanoma have shown clinical responses when treated with the… 
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