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PLK4 gene

Known as: PLK4, SAK, MOUSE, HOMOLOG OF, SERINE/THREONINE PROTEIN KINASE 18 
This gene plays a role in the formation of centrioles or basal bodies.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Centrioles are essential for ciliogenesis. However, mutations in centriole biogenesis genes have been reported in primary… Expand
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Highly Cited
2014
Highly Cited
2014
Formation of one procentriole next to each pre-existing centriole is essential for centrosome duplication, robust bipolar spindle… Expand
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Highly Cited
2011
Highly Cited
2011
Deregulated centrosome duplication can result in genetic instability and contribute to tumorigenesis. Here, we show that… Expand
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Highly Cited
2010
Highly Cited
2010
Cep152, the orthologue of Drosophila Asterless, is a Plk4 target that functions with Plk4 in centriole assembly. 
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Highly Cited
2010
Highly Cited
2010
Cep152 interacts with the cryptic Polo-box of Plk4 and is required for Plk4-induced centriole overduplication. 
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Highly Cited
2009
Highly Cited
2009
Centrioles are essential for the formation of microtubule-derived structures, including cilia and centrosomes. Abnormalities in… Expand
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Highly Cited
2009
Highly Cited
2009
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the… Expand
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Highly Cited
2005
Highly Cited
2005
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK… Expand
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Highly Cited
2005
Highly Cited
2005
The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell survival and postgastrulation… Expand
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