PLK4 gene

Known as: PLK4, SAK, MOUSE, HOMOLOG OF, SERINE/THREONINE PROTEIN KINASE 18 
This gene plays a role in the formation of centrioles or basal bodies.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
010203019742018

Papers overview

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2014
2014
Centrioles are essential for ciliogenesis. However, mutations in centriole biogenesis genes have been reported in primary… (More)
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Highly Cited
2009
Highly Cited
2009
Centrioles are essential for the formation of microtubule-derived structures, including cilia and centrosomes. Abnormalities in… (More)
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2008
2008
In eukaryotes, homologous recombination proteins such as RAD51 and RAD52 play crucial roles in DNA repair and genome stability… (More)
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Highly Cited
2007
Highly Cited
2007
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK… (More)
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Highly Cited
2005
Highly Cited
2005
The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell survival and postgastrulation… (More)
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Highly Cited
2005
Highly Cited
2005
Recently we described a novel bacteriophage-encoded pathogenicity island in Staphylococcus aureus that harbors a number of… (More)
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Highly Cited
2002
Highly Cited
2002
The small family of polo-like kinases (Plks) includes Cdc5 from Saccharomyces cerevisiae, Plo1 from Schizosaccharomyces pombe… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin (IL)-3-induced Bcl2 phosphorylation at Ser(70) may be required for its full and potent antiapoptotic activity… (More)
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Highly Cited
2001
Highly Cited
2001
Polo-like kinases in yeast, flies, and mammals regulate key events in mitosis. Such events include spindle formation at G2/M, the… (More)
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