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PLK4 gene

Known as: PLK4, SAK, MOUSE, HOMOLOG OF, SERINE/THREONINE PROTEIN KINASE 18 
This gene plays a role in the formation of centrioles or basal bodies.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle ControlG2 to M Transition ProcessPLK4 protein, humanPhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A functional screening of the kinome identifies the Polo‐like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain
Malignant rhabdoid tumors (MRTs) are deadly embryonal tumors of the infancy. With poor survival and modest response to available… 
2010
2010
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy
Polyploidy results from deregulated cell division and has been considered an undesirable event leading to increased mutation rate… 
Highly Cited
2009
Highly Cited
2009
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations… 
2009
2009
High-level expression of non-glycosylated and active staphylokinase from Pichia pastoris
Staphylokinase (SAK) is a promising thrombolytic agent for treating blood-clotting disorders. Recombinant SAK (rSAK) was produced… 
2001
2001
Sak Serine-Threonine Kinase Acts as an Effector of Tec Tyrosine Kinase*
The murine sak gene encodes a putative serine-threonine kinase which is homologous to the members of the Plk/Polo family… 
2000
2000
Analysis of plasminogen activation by the plasmin–staphylokinase complex in plasma of α2-antiplasmin-deficient mice
Staphylokinase (SAK) expresses plasminogen activator (PA) activity by forming a complex with plasmin; this PA activity is… 
1999
1999
Carrier design: new generation of polycationic branched polypeptides containing OH groups with prolonged blood survival and diminished in vitro cytotoxicity.
For the construction of macromolecule-drug conjugates, it is important to provide rational basis to the selection of proper… 
Highly Cited
1996
Highly Cited
1996
Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation
The murine Sak gene encodes two isoforms of a putative serine/threonine kinase, Sak-a and Sak-b, with a common N-terminal kinase… 
1994
1994
Functional properties of recombinant staphylokinase variants obtained by site-specific mutagenesis of methionine-26.
Highly Cited
1993
Highly Cited
1993
In vivo and in vitro phosphorylation of the T lymphocyte type n (Kv1.3) potassium channel.
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