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PKNOX1 gene

Known as: PBX/knotted 1 homeobox 1, PKNOX1, PBX-REGULATING PROTEIN 1 
National Institutes of Health

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1 relation
PKNOX1 protein, human

Papers overview

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2019
2019
Prep1 regulates angiogenesis through a PGC‐1α‐mediated mechanism
Angiogenesis depends on a delicate balance between the different transcription factors, and their control should be considered… 
2016
2016
The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability
PREP1/p160 is a protein complex with relevant physiopathological roles in vivo. p160 regulates PREP1 transcriptional activity by… 
2015
2015
Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element
Meis1 overexpression induces tumorigenicity but its activity is inhibited by Prep1 tumor suppressor. Why does overexpression of… 
2014
2014
The Deficiency of Tumor Suppressor Prep1 Accelerates the Onset of Meis1- Hoxa9 Leukemogenesis
Prep1 and Meis1 ortholog TALE transcription factors have opposing roles in tumorigenesis: Meis1 serves as an oncogene, Prep1 as a… 
2012
2012
Reduction of Prep1 Levels Affects Differentiation of Normal and Malignant B Cells and Accelerates Myc Driven Lymphomagenesis
The Prep1 homeodomain transcription factor has recently been recognized as a tumor suppressor. Among other features… 
2010
2010
Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress
PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be… 
2010
2010
Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
OBJECTIVE We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver. RESEARCH DESIGN AND… 
2008
2008
Prep1 Directly Regulates the Intrinsic Apoptotic Pathway by Controlling Bcl-XL Levels
ABSTRACT The Prep1 homeodomain transcription factor is essential in embryonic development. Prep1 hypomorphic mutant mouse (Prep1i… 
2007
2007
Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
Prep1 homeodomain transcription factor interacts with Pbx proteins to regulate oculogenesis, angiogenesis, and hematopoiesis in… 
Highly Cited
2002
Highly Cited
2002
Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors.
TALE (three amino acid loop extension) homeodomain proteins include the PBC and the MEINOX sub-families. MEINOX proteins form… 
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