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PKNOX1 gene

Known as: PBX/knotted 1 homeobox 1, PKNOX1, PBX-REGULATING PROTEIN 1 
National Institutes of Health

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1 relation
PKNOX1 protein, human

Papers overview

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2019
2019
Prep1 regulates angiogenesis through a PGC‐1α‐mediated mechanism
Angiogenesis depends on a delicate balance between the different transcription factors, and their control should be considered… 
2016
2016
The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability
PREP1/p160 is a protein complex with relevant physiopathological roles in vivo. p160 regulates PREP1 transcriptional activity by… 
2010
2010
Prep1 (pKnox1)‐deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1
2010
2010
Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress
PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be… 
2010
2010
Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
OBJECTIVE We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver. RESEARCH DESIGN AND… 
2008
2008
Prep1 Deficiency Induces Protection from Diabetes and Increased Insulin Sensitivity through a p160-Mediated Mechanism
ABSTRACT We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1… 
2008
2008
Prep1 Directly Regulates the Intrinsic Apoptotic Pathway by Controlling Bcl-XL Levels
ABSTRACT The Prep1 homeodomain transcription factor is essential in embryonic development. Prep1 hypomorphic mutant mouse (Prep1i… 
2007
2007
Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
Prep1 homeodomain transcription factor interacts with Pbx proteins to regulate oculogenesis, angiogenesis, and hematopoiesis in… 
Highly Cited
2002
Highly Cited
2002
Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors.
TALE (three amino acid loop extension) homeodomain proteins include the PBC and the MEINOX sub-families. MEINOX proteins form… 
Highly Cited
1998
Highly Cited
1998
The novel homeoprotein Prep1 modulates Pbx–Hox protein cooperativity
The products of the mammalian Pbx and Drosophila exd genes are able to interact with Hox proteins specifically and to increase… 
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