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PKN3 gene

Known as: PROTEIN KINASE N3, PKN3, PKNbeta 
National Institutes of Health

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1 relation
protein kinase Nbeta

Papers overview

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Highly Cited
2018
Highly Cited
2018
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification.
Despite recent clinical successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off… 
2018
2018
The interaction of p130Cas with PKN3 promotes malignant growth
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its… 
2014
2014
siRNA nanoparticles: the future of RNAi therapeutics for oncology?
siRNA clinical trials: state of the art With the emergence of siRNA-based nanomedicine as a powerful therapeutic strategy for… 
2012
2012
The interaction of PKN3 with RhoC promotes malignant growth
2011
2011
Site recognition and substrate screens for PKN family proteins.
The PRKs [protein kinase C-related kinases; also referred to as PKNs (protein kinase Ns)] are a kinase family important in… 
Highly Cited
2010
Highly Cited
2010
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
Purpose: Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate… 
Highly Cited
2004
Highly Cited
2004
PKN3 is required for malignant prostate cell growth downstream of activated PI 3‐kinase
Chronic activation of the phosphoinositide 3‐kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth… 
2001
2001
PKN Regulates Phospholipase D1 through Direct Interaction*
The association of phospholipase (PLD)-1 with protein kinase C-related protein kinases, PKNα and PKNβ, was analyzed. PLD1… 
2001
2001
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.
PKNbeta is a novel isoform of PKNalpha, which is one of the target protein kinases for the small GTPase Rho. By yeast two-hybrid… 
1999
1999
Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library. PKNbeta had… 
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