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PINK1 gene

Known as: PINK1, PTEN induced putative kinase 1, PTEN-INDUCED PUTATIVE KINASE 1 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
AMPK&agr;2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating… 
Review
2014
Review
2014
Genetics of Parkinson's disease--state of the art, 2013.
Highly Cited
2013
Highly Cited
2013
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria
Defective mitochondria exert deleterious effects on host cells. To manage this risk, mitochondria display several lines of… 
Highly Cited
2012
Highly Cited
2012
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that… 
Highly Cited
2011
Highly Cited
2011
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Loss-of-function mutations in the gene encoding the mitochondrial PTEN-induced putative kinase 1 (PINK1) are a major cause of… 
Highly Cited
2010
Highly Cited
2010
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD… 
Highly Cited
2010
Highly Cited
2010
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
Highly Cited
2010
Highly Cited
2010
A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1
Accumulating evidence indicates that dysfunction of mitochondria is a common feature of Parkinson disease. Functional loss of a… 
Highly Cited
2008
Highly Cited
2008
Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1
Highly Cited
2004
Highly Cited
2004
Novel PINK1 mutations in early‐onset parkinsonism
PINK1 was recently found to be associated with PARK6 as the causative gene. We performed mutation analysis in eight inbred… 
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