FAQ

PIK3CA NP_006209.2:p.H1047R

Known as: Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide H1047R, PIK3CA p.Glu1047Arg, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Alpha H1047R 
A change in the amino acid residue at position 1047 in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2018
012319972018

Papers overview

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2016
2016
Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas12
Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics… (More)
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2016
2016
Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in human breast cancer. Furthermore, PIK3CA mutations are… (More)
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2016
2016
Highly sensitive detection of the PIK3CAH1047R mutation in colorectal cancer using a novel PCR-RFLP method
The PIK3CA H1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we… (More)
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2014
2014
Formation and characterization of supported lipid bilayers containing phosphatidylinositol-4,5-bisphosphate and cholesterol as functional surfaces.
Solid-supported lipid bilayers (SLBs) mimicking a biological membrane are commonly used to investigate lipid-lipid or lipid… (More)
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Highly Cited
2011
Highly Cited
2011
The Akt-specific inhibitor MK2206 selectively inhibits thyroid cancer cells harboring mutations that can activate the PI3K/Akt pathway.
CONTEXT The phosphoinositide 3-kinase (PI3K)/Akt pathway is widely postulated to be an effective therapeutic target in thyroid… (More)
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Highly Cited
2011
Highly Cited
2011
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is… (More)
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2010
2010
WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.
The phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway is often… (More)
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Highly Cited
2008
Highly Cited
2008
Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers
Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-α catalytic subunit (encoded by… (More)
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2005
2005
Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels.
Presynaptic inhibition of transmitter release is commonly mediated by a direct interaction between G protein betagamma subunits… (More)
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Highly Cited
1997
Highly Cited
1997
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
Phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), a key molecule in the phosphoinositide signalling pathway, was thought to… (More)
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