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PIK3CA NP_006209.2:p.H1047R
Known as:
Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide H1047R
, PIK3CA p.Glu1047Arg
, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Alpha H1047R
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A change in the amino acid residue at position 1047 in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein…
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National Institutes of Health
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PIK3CA Gene Mutation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 3650: Use of unique molecular identifiers to gain insight about the true positive mutations in cfDNA of breast cancer patients for implementation of personalized treatment
C. Keup
,
Karim Benyaa
,
+5 authors
S. Kasimir-Bauer
Clinical research
2018
Corpus ID: 80706301
Background: Blood analytes, as liquid biopsies, are discussed to be surrogate markers for therapy stratification, as serial…
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2017
2017
Abstract 2715: Precision-designed, rapid and low-cost single molecule detection of mutations from circulating tumor DNA
Christina Wood-Bouwens
,
Christine Handy
,
Billy T. Lau
,
Hanlee P. Ji
2017
Corpus ID: 80286635
Detecting and quantifying mutations from circulating tumor DNA (ctDNA) is a new approach for longitudinally monitoring cancer…
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2016
2016
Highly sensitive detection of the PIK3CAH1047R mutation in colorectal cancer using a novel PCR-RFLP method
Wanming Li
,
Tingting Hu
,
Linlin Zhou
,
Yiming Feng
,
Yun-Yi Wang
,
Jin Fang
BMC Cancer
2016
Corpus ID: 255835408
The PIK3CAH1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we…
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2015
2015
Abstract 1119: Subclonal structure of breast cancer subtypes determined by quantitative analyses of activating mutations
Meagan B Myers
,
M. Banda
,
Karen L. McKim
,
B. Parsons
2015
Corpus ID: 78302656
Little is known about the role of low-frequency somatic mutations in breast cancer, a cancer that is quite variable in terms of…
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2015
2015
Abstract CT328: Exploratory genetic analysis of tumors from a phase I/II dose escalation study of GSK2636771 in patients (pts) with PTEN deficient advanced tumors
J. Bono
,
H. Arkenau
,
+22 authors
Rakesh Kumar
2015
Corpus ID: 79088284
Background: GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3Kβ (apparent Ki = 0.89 nM), with >900-fold…
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2014
2014
Abstract 1876: Combination of PI3KCA targeting with irradiation: A preclinical study on head and neck cancer cell lines
L. Lattanzio
,
F. Tonissi
,
+5 authors
G. Milano
2014
Corpus ID: 70764923
Purpose In complement to anti-EGFR therapy, the targeting of PI3KCA/AKT/mTOR signalling pathway is of particular interest in the…
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Highly Cited
2013
Highly Cited
2013
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
Diego A. Garcia-Dios
,
D. Lambrechts
,
+13 authors
F. Amant
Gynecologic Oncology
2013
Corpus ID: 2402860
Review
2012
Review
2012
PIK3CA/AKT1 Mutations in Breast Carcinoma: a Comprehensive Review of Experimental and Clinical Studies
M. Troxell
2012
Corpus ID: 76145740
The phosphatidylinositol-3-kinase (PI3K) pathway is an important nexus for integration of extracellular and intracellular signals…
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2012
2012
Abstract 3746: PI3K inhibition sensitizes to PARP inhibitors in patient-derived xenograft models of triple negative breast cancer
Y. Ibrahim
,
Celina García‐García
,
+11 authors
J. Baselga
2012
Corpus ID: 72684733
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Hyperactivation of the PI3K pathway through…
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2011
2011
Abstract 3072: Prospective study of genetic mutations in matched tumor and plasma specimens in advanced cancer patients referred to phase I trials
G. Perkins
,
J. Dukes
,
+7 authors
J. Bono
2011
Corpus ID: 71965528
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: Circulating free DNA (cfDNA) represents a…
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