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PIK 75

Known as: PIK-75 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

HydrazonesSulfonamides

Papers overview

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2014
2014
DW09849, a Selective Phosphatidylinositol 3-Kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation p110α (H1047R)
Phosphatidylinositol 3-kinase, α isoform (PI3Kα) plays essential roles in cell metabolism, growth, and proliferation and has been… 
2014
2014
The Inhibitory Effect of PIK-75 on Inflammatory Mediator Response Induced by Hydrogen Peroxide in Feline Esophageal Epithelial Cells
Isoform-selective inhibitors of phosphoinositide 3-kinase (PI3K) activation have an anti-inflammatory effect by reducing… 
2012
2012
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
The binding mechanism of a new class of lipid-competitive, ATP non-competitive, p110α isoform-selective PI3K (phosphoinositide 3… 
Highly Cited
2011
Highly Cited
2011
Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis
Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). ErbB3 binds… 
2010
2010
Class I Phospho-inositide-3-kinases (PI3Ks) Isoform-Specific Inhibition Study by the Combination of Docking and Molecular Dynamics Simulation
The combination of docking and molecular dynamics simulation is used to explain the isoform-specific selectivity between… 
2007
2007
Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform.
Platelets release insulin-like growth factor-1 (IGF-1) from alpha granules upon activation. We have investigated the regulation… 
2007
2007
Insulin-like growth factor-1 regulates platelet activation through PI 3K isoform
Platelets release insulin-like growth factor-1 (IGF-1) from granules upon activation. We have investigated the regulation of IGF… 
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