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PI3K-delta Inhibitor TGR-1202
Known as:
TGR-1202
An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with…
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National Institutes of Health
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2 relations
NCIt Antineoplastic Agent Terminology
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RP5264
Papers overview
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2018
2018
Abstract 871: BR101801: A first-in-class dual inhibitor of PI3Kδ and DNA-PK in non-Hodgkin's lymphoma
M. Son
,
Byeongwook Jeon
,
+6 authors
Dal-hyun Kim
Experimental and Molecular Therapeutics
2018
Corpus ID: 81333696
Introduction: Inhibition of PI3Kδ (idelialisib, TGR-1202) has been reported as having limited clinical benefits for the treatment…
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2017
2017
KI Intolerance Study: A Phase 2 Study to Assess the Safety and Efficacy of Umbralisib (TGR-1202) in Patients with Chronic Lymphocytic Leukemia (CLL) Who Are Intolerant to Prior BTK or PI3K…
A. Mato
,
B. Cheson
,
+17 authors
D. Brander
2017
Corpus ID: 79971975
Background: Although kinase inhibitor (KI) therapies such as ibrutinib are generally well tolerated, intolerance is the most…
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2016
2016
Silencing c-Myc Translation as a Therapeutic Strategy through Targeting PI 3 K Delta and CK 1 Epsilon in Hematological Malignancies Short title : Targeting PI 3 K and CK 1 in Myc Driven Lymphoma
C. Deng
,
Mark R. Lipstein
,
+18 authors
O’Connor
2016
Corpus ID: 207881935
Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin…
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2014
2014
Abstract 4711: The PI3K-δ inhibitor TGR-1202 in combination with Brentuximab Vedotin (SGN-35) synergistically induces G2/M phase arrest and cell death via inhibition of tubulin polymerization in…
S. Locatelli
,
S. Tartari
,
+5 authors
C. Carlo-Stella
2014
Corpus ID: 72644409
Introduction: The phosphatidylinositol 3-kinase (PI3K) pathway is consistently activated in relapsed/refractory Hodgkin lymphoma…
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2013
2013
TGR-1202: A NOVEL, PI3Kδ SPECIFIC INHIBITOR IN MULTIPLE MYELOMA
S. Vakkalanka
,
H. Miskin
,
P. Sportelli
,
S. Viswanadha
2013
Corpus ID: 85878893
P753 BACKGROUND TGR-1202 Presented at the 18th Congress of the European Hematology Association (EHA) June 13 – 16, 2013…
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