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PI3K-delta Inhibitor TGR-1202

Known as: TGR-1202 
An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with… (More)

Topic mentions per year

Topic mentions per year

2015-2017
012320152017

Papers overview

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2018
2018
Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.
BACKGROUND Umbralisib (TGR-1202) is a novel next-generation inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform p110δ (PI3K… (More)
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2017
2017
Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies.
Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin… (More)
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Review
2017
Review
2017
Novel synthetic drugs currently in clinical development for chronic lymphocytic leukemia.
INTRODUCTION Over the last few years, several new synthetic drugs, particularly Bruton's tyrosine kinase (BTK… (More)
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Review
2017
Review
2017
Possible novel agents in marginal zone lymphoma.
Efficacy, safety and mechanisms of action of novel agents in marginal zone lymphoma patients, both with a nodal and extranodal… (More)
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2016
2016
The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest
Despite a variety of novel therapeutic options in Hodgkin lymphoma (HL), treatment of primary refractory and earlyrelapsed… (More)
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Review
2016
Review
2016
The PI3K pathway: clinical inhibition in chronic lymphocytic leukemia.
Constitutive or mutational activation of the phosphatidylinositol 3 kinase, or PI3K, has been implicated in many cancers… (More)
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2015
2015
Childhood Cancer Survivors: The Long Road Ahead.
n ew s 7069, http://meetinglibrary.asco.org/ content/152042–156). This drug lacks the liver and gastrointestinal side effects… (More)
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