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PI3K-delta Inhibitor AMG 319
Known as:
AMG 319
A highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA…
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National Institutes of Health
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2012
2012
AMG 319, a Novel Inhibitor of Phosphoinositide-3 Kinase Delta (PI3Kd), Demonstrates Activity in Lymphoma Pre-Clinical Models
Amanda Herko
,
C. Mavis
,
M. Czuczman
,
F. Hernandez
2012
Corpus ID: 208410753
Abstract 3718 The PI3k/AKT/mTOR signaling pathway has been found to be deregulated in patients with various subtypes of B-cell…
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2011
2011
Phosphatidylinsoitol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Combined with Vincristine Enhances G2/M Arrest and Apoptotic Death in Neoplastic B Cells
Liqin Liu
,
Bee-Chun Sun
,
+5 authors
A. Sinclair
2011
Corpus ID: 208433555
Abstract 4963 Phosphatidylinositol-3 kinase delta (PI3Kδ) is a class IA lipid kinase expressed primarily in leukocytes and is a…
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2011
2011
Phosphatidylinositol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Is a Potent, Selective and Orally Bioavailable Small Molecule Inhibitor That Suppresses PI3K-Mediated Signaling and Viability in…
A. Sinclair
,
D. Metz
,
+12 authors
G. Molineux
2011
Corpus ID: 78918487
Abstract 4964 Immune receptors such as the B cell receptor (BCR) require key signaling intermediate phosphatidylinositol-3 kinase…
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