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PHF8 gene

Known as: PHD FINGER PROTEIN 8, PHF8, JHDM1F 
National Institutes of Health

Related topics

Related topics

1 relation
PHF12 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.
The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and… 
Highly Cited
2013
Highly Cited
2013
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Highly Cited
2012
Highly Cited
2012
Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion
Our understanding of key epigenetic regulators involved in specific biological processes and cancers is still incomplete, despite… 
Highly Cited
2010
Highly Cited
2010
PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for… 
Highly Cited
2010
Highly Cited
2010
The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability. Causal mutations have been… 
Highly Cited
2010
Highly Cited
2010
A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation
Highly Cited
2010
Highly Cited
2010
PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
ABSTRACT Mutations in PHF8 are associated with X-linked mental retardation and cleft lip/cleft palate. PHF8 contains a plant… 
Highly Cited
2010
Highly Cited
2010
Structural insights into a novel histone demethylase PHF8
Dynamic regulation of histone methylation/demethylation plays an important role during development. Mutations and truncations in… 
Highly Cited
2010
Highly Cited
2010
The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation
Recent studies have identified mutations in PHF8, an X-linked gene encoding a JmjC domain-containing protein, as a causal factor… 
Highly Cited
2010
Highly Cited
2010
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis
Dimethylation of histone H3 lysine 9 (H3K9me2) is an important epigenetic mark associated with transcription repression. Here, we… 
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