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PHC1 gene

Known as: POLYHOMEOTIC, DROSOPHILA, HOMOLOG OF, 1, PHC1, HUMAN POLYHOMEOTIC HOMOLOG 1 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis.
Primary microcephaly (PM) is a developmental disorder of early neuroprogenitors that results in reduction of the brain mass… Expand
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Highly Cited
2007
Highly Cited
2007
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
OBJECTIVES Polycomb group (PcG) proteins are involved in maintenance of cell identity and proliferation. The protein EZH2 is… Expand
Highly Cited
2006
Highly Cited
2006
Genetic Architecture of Hsp90-Dependent Drug Resistance
ABSTRACT Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic… Expand
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Highly Cited
2004
Highly Cited
2004
Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines.
Human Polycomb-group (PcG) genes play a crucial role in the regulation of embryonic development and regulation of the cell cycle… Expand
Highly Cited
2004
Highly Cited
2004
Hph1p and Hph2p, Novel Components of Calcineurin-Mediated Stress Responses in Saccharomyces cerevisiae
ABSTRACT Calcineurin is a Ca2+- and calmodulin-dependent protein phosphatase that plays a key role in animal and yeast physiology… Expand
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Highly Cited
2003
Highly Cited
2003
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1
Gain of 12p material is invariably associated with testicular germ cell tumors (TGCTs) of adolescents and adults, most usually as… Expand
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Highly Cited
2002
Highly Cited
2002
Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells
The rae28 gene (rae28), also designated as mph1, is a mammalian ortholog of the Drosophila polyhomeotic gene, a member of… Expand
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Highly Cited
1998
Highly Cited
1998
RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes.
The Polycomb group loci in Drosophila encode chromatin proteins required for repression of homeotic loci in embryonic development… Expand
Highly Cited
1997
Highly Cited
1997
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
The Polycomb (Pc) protein is a component of a multimeric, chromatin-associated Polycomb group (PcG) protein complex, which is… Expand
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Highly Cited
1997
Highly Cited
1997
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
In Drosophila melanogaster, the Polycomb-group (PcG) genes have been identified as repressors of gene expression. They are part… Expand
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