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PHC1 gene

Known as: POLYHOMEOTIC, DROSOPHILA, HOMOLOG OF, 1, PHC1, HUMAN POLYHOMEOTIC HOMOLOG 1 
 
National Institutes of Health

Papers overview

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2014
2014
EDR1 Physically Interacts with MKK4/MKK5 and Negatively Regulates a MAP Kinase Cascade to Modulate Plant Innate Immunity
Mitogen-activated protein (MAP) kinase signaling cascades play important roles in the regulation of plant defense. The Raf-like… Expand
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2013
2013
Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis.
Primary microcephaly (PM) is a developmental disorder of early neuroprogenitors that results in reduction of the brain mass… Expand
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Highly Cited
2007
Highly Cited
2007
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
OBJECTIVES Polycomb group (PcG) proteins are involved in maintenance of cell identity and proliferation. The protein EZH2 is… Expand
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Highly Cited
2006
Highly Cited
2006
Genetic architecture of Hsp90-dependent drug resistance.
Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen… Expand
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Highly Cited
2004
Highly Cited
2004
Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines.
Human Polycomb-group (PcG) genes play a crucial role in the regulation of embryonic development and regulation of the cell cycle… Expand
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2004
2004
Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.
Calcineurin is a Ca2+- and calmodulin-dependent protein phosphatase that plays a key role in animal and yeast physiology. In the… Expand
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Highly Cited
2003
Highly Cited
2003
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1
Gain of 12p material is invariably associated with testicular germ cell tumors (TGCTs) of adolescents and adults, most usually as… Expand
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2003
2003
Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus.
Human Polycomb group (PcG) proteins are involved in cell-type-dependent epigenetic gene silencing in an evolutionarily conserved… Expand
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Highly Cited
2002
Highly Cited
2002
Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells
The rae28 gene (rae28), also designated as mph1, is a mammalian ortholog of the Drosophila polyhomeotic gene, a member of… Expand
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2002
2002
The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis.
The Polycomb-group (PcG) gene Rae28 is a mammalian homologue of the Drosophila gene polyhomeotic. PcG genes are known to maintain… Expand
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