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PFKFB3 gene

Known as: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 Gene, PFKFB, PLACENTAL 
This gene plays a role in carbohydrate metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
6-Phosphofructo-2-kinaseCarbohydrate MetabolismDephosphorylationGlycolysis

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PFKFB3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells
Due to the high-level of metastatic and relapsed rates, rhabdomyosarcoma (RD) patients have a poor prognosis, and novel treatment… 
2018
2018
Discover potential inhibitors for PFKFB3 using 3D-QSAR, virtual screening, molecular docking and molecular dynamics simulation
Abstract The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis in cancer cells… 
2017
2017
Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells
Taxanes represent some of the most commonly used chemotherapeutic agents for ovarian cancer treatment. However, they are only… 
2016
2016
Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition
Neoplastic cells metabolize higher amounts of glucose relative to normal cells in order to cover increased energetic and anabolic… 
2016
2016
PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production.
Paclitaxel is a commonly used agent for breast cancer therapy, which comes across the obstacle "drug resistance", resulting in… 
Review
2014
Review
2014
Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle
Recent studies have given us a clue as to how modulations of both metabolic pathways and cyclins by the ubiquitin system… 
2013
2013
Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
2012
2012
Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH.
Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering… 
2009
2009
Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals
The ubiquitous isoform of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (uPFK‐2), a product of the Pfkfb3 gene, plays a… 
Highly Cited
2008
Highly Cited
2008
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) controls the glycolytic flux via… 
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