PFKFB3 gene

Known as: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 Gene, PFKFB, PLACENTAL 
This gene plays a role in carbohydrate metabolism.
National Institutes of Health

Papers overview

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2015
2015
Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells… (More)
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Highly Cited
2014
Highly Cited
2014
Strategies targeting pathological angiogenesis have focused primarily on blocking vascular endothelial growth factor (VEGF), but… (More)
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2014
2014
OBJECTIVE Vascular cells, particularly endothelial cells, adopt aerobic glycolysis to generate energy to support cellular… (More)
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Highly Cited
2014
Highly Cited
2014
Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling… (More)
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Highly Cited
2013
Highly Cited
2013
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled by genetic signals (such as Notch… (More)
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Highly Cited
2013
Highly Cited
2013
In the HLA class II-associated autoimmune syndrome rheumatoid arthritis (RA), CD4 T cells are critical drivers of pathogenic… (More)
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2012
2012
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis by its ability to synthesize… (More)
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Highly Cited
2009
Highly Cited
2009
The regulation of metabolism and growth must be tightly coupled to guarantee the efficient use of energy and anabolic substrates… (More)
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Highly Cited
2008
Highly Cited
2008
6-phosphofructo-1-kinase, a rate-limiting enzyme of glycolysis, is activated in neoplastic cells by fructose-2,6-bisphosphate… (More)
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Highly Cited
2002
Highly Cited
2002
One of the key mediators of the hypoxic response in animal cells is the hypoxia-inducible transcription factor-1 (HIF-1) complex… (More)
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