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PF-2545920

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract A76: Targeting phosphodiesterase 10A for chemoprevention and treatment of ovarian cancer.
Phosphodiesterase 10A (PDE10A) is a dual cyclic AMP and cyclic GMP phosphodiesterase that is highly expressed in the brain… 
2016
2016
Abstract 331: Beta-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG
Phosphodiesterase 10A (PDE10A) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it… 
2014
2014
Abstract 1762: Phosphodiesterase 10, a novel target for colorectal cancer therapeutics
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Phosphodiesterase 10 (PDE10) is a newly characterized PDE… 
2014
2014
PDE10 inhibitors suppress lung tumor growth in mice.
e22187 Background: Phosphodiesterase 10 has been studied in the brain as a therapeutic target for psychiatric and neurological… 
2014
2014
Abstract 1761: PDE10, a novel therapeutic target for lung cancer
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Phosphodiesterase 10A (PDE10) is a relatively new PDE… 
2013
2013
Combating Lung Cancer Metastasis by Raising Intracellular cAMP Concentration
Abstract : ERK signaling pathway plays a critical role in the survival and proliferation of invasive lung cancer cells. However… 
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