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PF-01247324

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice
Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the… 
2020
2020
Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia.
2018
2018
The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy
In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is enhanced. We aimed to investigate the… 
2018
2018
Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart
Aims In heart failure (HF), enhanced persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and… 
2018
2018
NaV1.8: a novel contributor to cardiac arrhythmogenesis in heart failure.
NaV1.8 is a tetrodotoxin-resistant Naþ channel with a slow inactivation kinetics first identified in dorsal root ganglion sensory… 
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