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Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the… Expand OBJECTIVE
In myocardial pathology such as heart failure a late sodium current (INaL) augmentation is known to be involved in… Expand In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is enhanced. We aimed to investigate the… Expand The action potential initiation in the nerve terminals and its subsequent conduction along the axons of afferent nerves are not… Expand Aims
In heart failure (HF), enhanced persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and… Expand NaV1.8 is a tetrodotoxin-resistant Naþ channel with a slow inactivation kinetics first identified in dorsal root ganglion sensory… Expand NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of… Expand Cerebellar symptoms significantly diminish quality of life in patients with multiple sclerosis (MS). We previously showed that… Expand