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PF-01247324

 
National Institutes of Health

Papers overview

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2020
2020
Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the… Expand
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2020
2020
OBJECTIVE In myocardial pathology such as heart failure a late sodium current (INaL) augmentation is known to be involved in… Expand
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2019
2019
In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is enhanced. We aimed to investigate the… Expand
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2018
2018
The action potential initiation in the nerve terminals and its subsequent conduction along the axons of afferent nerves are not… Expand
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2018
2018
Aims In heart failure (HF), enhanced persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and… Expand
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2018
2018
NaV1.8 is a tetrodotoxin-resistant Naþ channel with a slow inactivation kinetics first identified in dorsal root ganglion sensory… Expand
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2015
2015
NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of… Expand
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2015
2015
Cerebellar symptoms significantly diminish quality of life in patients with multiple sclerosis (MS). We previously showed that… Expand
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