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PEX16 gene

Known as: PEX16, peroxisomal biogenesis factor 16, PEROXISOME BIOGENESIS FACTOR 16 
 
National Institutes of Health

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Highly Cited
2017
Highly Cited
2017
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
Peroxisomes function together with mitochondria in a number of essential biochemical pathways, from bile acid synthesis to fatty… Expand
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2015
2015
Multiple Domains in PEX16 Mediate Its Trafficking and Recruitment of Peroxisomal Proteins to the ER.
Peroxisomes rely on a diverse array of mechanisms to ensure the specific targeting of their protein constituents. Peroxisomal… Expand
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2014
2014
PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER
The endoplasmic reticulum (ER) is required for the de novo biogenesis of peroxisomes in mammalian cells. However, its role in… Expand
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2011
2011
Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.
Sec16 plays a key role in the formation of coat protein II vesicles, which mediate protein transport from the endoplasmic… Expand
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2010
2010
Identification of an unusual variant peroxisome biogenesis disorder caused by mutations in the PEX16 gene.
BACKGROUND Zellweger syndrome spectrum disorders are caused by mutations in any of at least 12 different PEX genes. This includes… Expand
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Review
2009
Review
2009
How peroxisomes multiply.
With every cell division, peroxisomes duplicate and are segregated between progeny cells. Here, we discuss the different modes of… Expand
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Highly Cited
2006
Highly Cited
2006
The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER
Peroxisomes are ubiquitous organelles that proliferate under different physiological conditions and can form de novo in cells… Expand
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Highly Cited
1999
Highly Cited
1999
Peroxisome Synthesis in the Absence of Preexisting Peroxisomes
Zellweger syndrome and related diseases are caused by defective import of peroxisomal matrix proteins. In all previously reported… Expand
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Highly Cited
1998
Highly Cited
1998
Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D.
Peroxisome-biogenesis disorders (PBDs), including Zellweger syndrome (ZS), are autosomal recessive diseases caused by a… Expand
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Highly Cited
1997
Highly Cited
1997
Enlarged Peroxisomes Are Present in Oleic Acid–grown Yarrowia lipolytica Overexpressing the PEX16 Gene Encoding an Intraperoxisomal Peripheral Membrane Peroxin
Pex mutants of the yeast Yarrowia lipolytica are defective in peroxisome assembly. The mutant strain pex16-1 lacks… Expand
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