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PD 166793

Known as: PD-166793, PD166793 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II*
Background: TIMP3 is ECM-bound and is implicated in patients with abdominal aortic aneurysm (AAA). Results: Timp3 deficiency… 
Highly Cited
2009
Highly Cited
2009
Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction
Osteopontin (OPN) plays an important role in left ventricular (LV) remodeling after myocardial infarction (MI) by promoting… 
Highly Cited
2007
Highly Cited
2007
Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.
Highly Cited
2005
Highly Cited
2005
Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice
Cytokine and extracellular matrix (ECM) homeostasis are distinct systems that are each dysregulated in heart failure. Here we… 
Highly Cited
2003
Highly Cited
2003
Myocardial Infarct Expansion and Matrix Metalloproteinase Inhibition
Background—A potential mechanism for left ventricular (LV) remodeling after myocardial infarction (MI) is activation of the… 
Highly Cited
2003
Highly Cited
2003
Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction.
Highly Cited
2003
Highly Cited
2003
Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs.
BACKGROUND Global and regional shape changes that occur within the left ventricular wall after myocardial infarction have been… 
Highly Cited
2002
Highly Cited
2002
Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.
Highly Cited
2001
Highly Cited
2001
Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure
BackgroundMatrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP… 
Highly Cited
1999
Highly Cited
1999
Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function.
The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The… 
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