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PD 166793

Known as: PD-166793, PD166793 
 
National Institutes of Health

Papers overview

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2012
2012
Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.
Collagen-I is thought to be the main component of the extracellular matrix in cardiac fibrosis, the accumulation of which occurs… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction
Osteopontin (OPN) plays an important role in left ventricular (LV) remodeling after myocardial infarction (MI) by promoting… Expand
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Highly Cited
2007
Highly Cited
2007
Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.
Matrix metalloproteinase (MMP)-2 mediates myocardial ischemia-reperfusion injury which is characterized by enhanced peroxynitrite… Expand
Highly Cited
2005
Highly Cited
2005
Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice
Cytokine and extracellular matrix (ECM) homeostasis are distinct systems that are each dysregulated in heart failure. Here we… Expand
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Highly Cited
2003
Highly Cited
2003
Myocardial Infarct Expansion and Matrix Metalloproteinase Inhibition
Background—A potential mechanism for left ventricular (LV) remodeling after myocardial infarction (MI) is activation of the… Expand
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2003
2003
Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs.
BACKGROUND Global and regional shape changes that occur within the left ventricular wall after myocardial infarction have been… Expand
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Highly Cited
2003
Highly Cited
2003
Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction.
OBJECTIVE Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxynitrite production, yet the… Expand
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Highly Cited
2001
Highly Cited
2001
Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure
BackgroundMatrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP… Expand
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Highly Cited
1999
Highly Cited
1999
Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function.
The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The… Expand
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1999
1999
Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.
Matrix metalloproteinases (MMPs) are implicated in diseases such as arthritis and cancer. Among these enzymes, stromelysin-1 can… Expand
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