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PD 166793

Known as: PD-166793, PD166793 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2016
02419992016

Papers overview

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2012
2012
Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Aortic aneurysm is dilation of the aorta primarily due to degradation of the aortic wall extracellular matrix (ECM). Tissue… (More)
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Highly Cited
2005
Highly Cited
2005
Expression of MMP2, MMP9 and MMP3 in Breast Cancer Brain Metastasis in a Rat Model
In order to study the expression of MMP2, MMP3 and MMP9 in breast cancer brain metastasis, we used a syngeneic rat model of… (More)
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2005
2005
Matrix metalloproteinases contribute to insulin insufficiency in Zucker diabetic fatty rats.
To assess the molecular changes associated with pancreatic beta-cell dysfunction occurring during the onset of type 2 diabetes… (More)
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Highly Cited
2003
Highly Cited
2003
Myocardial infarct expansion and matrix metalloproteinase inhibition.
BACKGROUND A potential mechanism for left ventricular (LV) remodeling after myocardial infarction (MI) is activation of the… (More)
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2003
2003
Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs.
BACKGROUND Global and regional shape changes that occur within the left ventricular wall after myocardial infarction have been… (More)
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2003
2003
Matrix metalloproteinase abundance in human myocardial fibroblasts: effects of sustained pharmacologic matrix metalloproteinase inhibition.
BACKGROUND A cause-effect relationship has been established between matrix metalloproteinases (MMPs) and left ventricular (LV… (More)
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Highly Cited
2002
Highly Cited
2002
Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.
OBJECTIVES Peroxynitrite (ONOO(-)) mediates in part both ischemia-reperfusion and pro-inflammatory cytokine-induced injury to the… (More)
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Highly Cited
2001
Highly Cited
2001
Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
BACKGROUND Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased… (More)
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Highly Cited
2000
Highly Cited
2000
MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition.
OBJECTIVE Determine the effect of a matrix metalloproteinase inhibitor (MMPi) and angiotensin converting enzyme inhibitor (ACEi… (More)
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Highly Cited
1999
Highly Cited
1999
Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function.
The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The… (More)
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