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PD 156707

Known as: PD-156707 
National Institutes of Health

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1 relation

Broader (1)

Dioxoles

Papers overview

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2009
2009
PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies.
2002
2002
The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb.
Endothelin-1 (ET-1) is considered an intermediary in the constrictor response of the pulmonary vasculature to hypoxia and, by… 
Highly Cited
2001
Highly Cited
2001
ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.
Recent studies implicate reactive oxygen species (ROS) such as superoxide anions and H(2)O(2) in the proliferation of systemic… 
1999
1999
Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow.
1998
1998
Endothelin Receptor Blockade Does Not Alter Closure of the Ductus Arteriosus• 332
Endothelin-1 (ET-1) is synthesized within the wall of the ductus arteriosus (DA) and is a potent constrictor of the DA in vitro… 
Review
1998
Review
1998
Discovery and development of an endothelin A receptor-selective antagonist PD 156707.
PD 156707 is a highly potent, selective antagonist of the ETA receptor that has demonstrated efficacy in a number of different… 
1996
1996
Endothelins and endothelin receptor antagonists: binding to plasma proteins.
1996
1996
Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs.
Episodes of myocardial ischemia are associated with increases in cardiac venous plasma endothelin (ET) concentrations, suggesting… 
Highly Cited
1996
Highly Cited
1996
Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart.
We have proposed that ischemic preconditioning in rabbit hearts is initiated by adenosine receptor stimulation resulting in… 
Highly Cited
1995
Highly Cited
1995
Pharmacological characterization of PD 156707, an orally active ETA receptor antagonist.
We describe the pharmacological characteristics of PD 156707 (sodium 2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5… 
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