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PD 151746

Known as: PD-151746, PD151746 
 
National Institutes of Health

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1 relation

Broader (1)

Acrylates

Papers overview

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2018
2018
Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling
Enriched environment (EE) has been shown to promote neurogenesis and functional recovery after ischemic stroke. However, the… Expand
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Highly Cited
2016
Highly Cited
2016
Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.
We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE) at 2p23 spanning the calpain 14… Expand
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2014
2014
In Silico Affinity Profiling of Neuroactive Polyphenols for Post-Traumatic Calpain Inactivation: A Molecular Docking and Atomistic Simulation Sensitivity Analysis
Calcium-activated nonlysosomal neutral proteases, calpains, are believed to be early mediators of neuronal damage associated with… Expand
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2012
2012
Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death.
P2X7 receptor (P2X7R) is known to be a 'death receptor' in immune cells, but its functional expression in non-immune cells such… Expand
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2011
2011
Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation.
Calpain inhibitors, including peptide aldehydes (N-acetyl-Leu-Leu-Nle-CHO and N-acetyl-Leu-Leu-Met-CHO) and α-mercapto-acrylic… Expand
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2011
2011
Calpain inhibitors stimulate phagocyte functions via activation of human formyl peptide receptors.
Calpain inhibitors induce pertussis toxin (PTx)-sensitive chemotaxis in human neutrophils and monocytes. Here, we show that… Expand
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2005
2005
Inhibition of the cdk5/MEF2 pathway is involved in the antiapoptotic properties of calpain inhibitors in cerebellar neurons.
Experimental data implicate calpain activation in the pathways involved in neuronal apoptosis. Indeed, calpain inhibitors confer… Expand
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2005
2005
Specific Proteolysis of Neuronal Protein GAP-43 by Calpain: Characterization, Regulation, and Physiological Role
The mechanism of specific proteolysis of the neuronal protein GAP-43 in axonal terminals has been investigated. In synaptic… Expand
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Highly Cited
1997
Highly Cited
1997
Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.
Calpain (calcium-activated neutral protease) has been implicated as playing a role of neuronal injury in cerebral ischemia and… Expand
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Highly Cited
1996
Highly Cited
1996
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
Overactivation of calcium-activated neutral protease (calpain) has been implicated in the pathophysiology of several degenerative… Expand
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